gingival fibromatosis 1

gingival fibromatosis 1

A rare autosomal dominant condition (OMIM:135300) characterised by a benign, slowly progressive, nonhaemorrhagic, fibrous enlargement of maxillary and mandibular keratinised gingivae.

Molecular pathology
Caused by defects of SOS1, which encodes a guanine nucleotide exchange factor for RAS proteins, a family of membrane proteins that bind guanine nucleotides and participate in signal transduction pathways.