giant platelet

A platelet that is larger than usual—e.g., the size of an RBC—a finding typical of Bernard-Soulier syndrome (BSS); up to 10% of normal platelets are ‘giant’—i.e., ‘squashed’ and oversized
DiffDx When > 20% of platelets are giant: idiopathic thromocytopaenic purpura (ITP), lymphoproliferative disorders, myeloproliferative disorders, reticulocytosis, disseminated intravascular coagulation (DIC), systemic lupus (SLE), grey platelet syndrome, May-Hegglin anomaly, type 2B von Willebrand’s disease, thrombotic thrombocytopaenic purpura (TTP)

giant platelet

A platetet that is larger than usual, a finding typical of Bernard-Soulier syndrome–BSS; up to 10% of normal platelets are 'giant', ie 'squashed' and oversized; when > 20% of platelets are giant, other conditions must be considered in addition to BSS–eg, ITP, lympho- and myeloproliferative disorders, reticulocytosis, DIC, SLE, gray platelet syndrome, May-Hegglin anomaly, Montreal platelet syndrome, TTP
References in periodicals archive ?
Few disclaimers have to be considered while one interprets MPV in isolation: a spurious increase in MPV contributed by red blood cell fragmentation which can be counted by the analyzer as a giant platelet, a combination of hypoproductive and hyperdestructive thrombocytopenia and splenic sequestration; where large platelets are entrapped in spleen but not released into the circulation.
Platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (15).
Inherited giant platelet disorders: classification and literature review.
However, platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (12).
28) Giant platelet disorders also have characteristic electron microscopic findings.
A giant platelet is defined as a platelet larger than a red cell (typically > 100 fL) but we know that particles >35 fL may impact the WBC count.
2]-AP assay vWD vWF Ag and activity 12 h Factor VIII level Ristocetin-induced platelet aggregation [+ or -] multimer analysis Inherited platelet Platelet count N/[down In vivo: ~5 d defects arrow] Microscopy: may reveal Transfused: giant platelets Platelet aggregometry 3-4 d ([double Flow cytometry [down dagger]) arrow] EM of platelet ultrastructure INR = international normalised ratio; PT = prothrombin time; PTT = partial thromboplastin time; TT = thrombin time; UCLT = urea clot lysis time; PFA = platelet function assay; [[alpha].
However, MPV may not be an accurate indication of immaturity because of interference from giant platelets, platelet clumps, microerythrocytes, and cell fragments.
The measurement of giant platelets (greater than 40 fl), with the correct grade PLT harvesting at each measurement.
Increased proportion of giant platelets and platelet distribution width are better indicators of altered platelet homeostasis than mean platelet volume in liver cirrhosis.
Bernard-Soulier syndrome lacks a platelet response only for ristocetin and is associated with thrombocytopenia and giant platelets.
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes (burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes 2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.