giant platelet

A platelet that is larger than usual—e.g., the size of an RBC—a finding typical of Bernard-Soulier syndrome (BSS); up to 10% of normal platelets are ‘giant’—i.e., ‘squashed’ and oversized
DiffDx When > 20% of platelets are giant: idiopathic thromocytopaenic purpura (ITP), lymphoproliferative disorders, myeloproliferative disorders, reticulocytosis, disseminated intravascular coagulation (DIC), systemic lupus (SLE), grey platelet syndrome, May-Hegglin anomaly, type 2B von Willebrand’s disease, thrombotic thrombocytopaenic purpura (TTP)

giant platelet

A platetet that is larger than usual, a finding typical of Bernard-Soulier syndrome–BSS; up to 10% of normal platelets are 'giant', ie 'squashed' and oversized; when > 20% of platelets are giant, other conditions must be considered in addition to BSS–eg, ITP, lympho- and myeloproliferative disorders, reticulocytosis, DIC, SLE, gray platelet syndrome, May-Hegglin anomaly, Montreal platelet syndrome, TTP
References in periodicals archive ?
Platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (15).
Giant platelet disorders also have characteristic electron microscopic findings.
Inherited giant platelet disorders: classification and literature review.
However, platelet-rich plasma is an artificial milieu deficient in giant platelet subspecies as well as erythrocytes and leukocytes, which are regarded as critical modulators of platelet function in vivo (12).
A giant platelet is defined as a platelet larger than a red cell (typically > 100 fL) but we know that particles >35 fL may impact the WBC count.
The measurement of giant platelets (greater than 40 fl), with the correct grade PLT harvesting at each measurement.
For example, a high take off of the WBC histogram can be caused by several elements, such as nucleated red blood cells (nRBCs), giant platelets, platelet clumps, and even intra-cellular parasites from RBCs that get released during the lysing process.
Bernard-Soulier syndrome lacks a platelet response only for ristocetin and is associated with thrombocytopenia and giant platelets.
WBC Toxic granulations 28 Dohle bodies 5 Vacuolations 38 Smudge cells 32 Clefted lymphocytes 10 Hairy projections 2 Auer rods 2 RBC Anisocytosis 54 Poikilocytosis 31 Microcytosis 7 Macrocytosis 2 Hypochromasia 3 Polychromasia 35 Echinocytes (burr cells) 19 Dacrocytes (teardrops) 16 Spherocytes 6 Target cells 2 Acanthocytes 1 Ovalocytes 28 Schistocytes 5 Stomatocytes 2 Howell-Jolly bodies 1 Basophilic stipplings 5 Platelet Clumped platelets 3 Platelet satellitosis 5 Large platelets 8 Giant platelets 8 Overall Cell Morphology Code Concordance, Overall Type % Concordance, % WBC Toxic granulations 78.
It is well established that essential thrombocytosis in myeloproliferative diseases is associated with an increased risk of thrombosis due to the presence of giant platelets (1).
The presence of giant platelets in the peripheral blood supports the diagnosis of ET.