giant peristaltic contraction

giant peristaltic contraction

a propulsive contraction of the bowel that normally occurs periodically in the distal small intestine and colon. The contractions are 1.5 to 2 times larger than normal in amplitude and 4 to 6 times longer in duration than usual. In certain disease states, giant peristaltic contractions may start in the proximal small intestine and proceed uninterrupted. They may also be induced by a variety of stimuli including certain antibiotics, radiation therapy, and parasitic infections.
A prolonged, high-amplitude forward propagating contraction that represents a heightened peristaltic contraction. Giant peristaltic contractions may be induced by cholera toxin, occur in patients with irritable bowel syndrome, and be identical to the migrating action potential complex

giant peristaltic contraction

GI disease A prolonged, high-amplitude forward propagating contraction that represents a heightened peristaltic contraction; GPCs may be induced by cholera toxin, are present in Pts with irritable bowel syndrome, and identical in nature to the migrating action potential complex. Cf Local reflex peristalsis.
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