Ménétrier’s disease

(redirected from giant hypertrophy of gastric rugae)

Ménétrier’s disease

A condition characterised by enlarged rugal folds of the stomach, late development of parietal cell autoantibodies and gastric atrophy.
 
Clinical findings
Decreased acid secretion, protein loss in the stomach, oedema, weight loss, abdominal pain, nausea and hypertrophic hypersecretory gastropathy; male:female ratio, 3:1; age 30–60.

Management
May respond to cetuximab, anticholinergics, cimetidine, vagotomy and pyloroplasty.