giant follicular lymphoma

lymphoma /lym·pho·ma/ (lim-fo´mah) any neoplastic disorder of lymphoid tissue. Often used to denote malignant l., classifications of which are based on predominant cell type and degree of differentiation; various categories may be subdivided into nodular and diffuse types depending on the predominant pattern of cell arrangement.

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adult T-cell lymphoma , adult T-cell leukemia/lymphoma see under leukemia.

B-cell lymphoma  any in a large group of non-Hodgkin's lymphomas characterized by malignant transformation of the B lymphocytes.

B-cell monocytoid lymphoma  a low-grade lymphoma in which cells resemble those of hairy cell leukemia.

Burkitt's lymphoma  a form of small noncleaved-cell lymphoma, usually occurring in Africa, manifested usually as a large osteolytic lesion in the jaw or as an abdominal mass; Epstein-Barr virus has been implicated as a causative agent.

centrocytic lymphoma  mantle cell l.

convoluted T-cell lymphoma  lymphoblastic lymphoma with markedly convoluted nuclei.

cutaneous T-cell lymphoma  a group of lymphomas exhibiting (1) clonal expansion of malignant T lymphocytes arrested at varying stages of differentiation of cells committed to the series of helper T cells, and (2) malignant infiltration of the skin, which may be the chief or only manifestation of disease.

diffuse lymphoma  in an older classification method, malignant lymphoma in which the neoplastic cells diffusely infiltrate the entire lymph node, without any definite organized pattern.

follicular lymphoma  any of several types of non-Hodgkin's lymphoma in which the lymphomatous cells are clustered into nodules or follicles.

follicular center cell lymphoma  B-cell lymphoma classified by the similarity of the cell size and nuclear characteristics to those of normal follicular center cells; the four previous subtypes are scattered among several types of follicular and diffuse lymphomas.

giant follicular lymphoma  follicular l.

granulomatous lymphoma  Hodgkin's disease.

histiocytic lymphoma  a rare type of non-Hodgkin's lymphoma characterized by the presence of large tumor cells resembling histiocytes morphologically but considered to be of lymphoid origin.

Hodgkin's lymphoma  see under disease.

intermediate lymphocytic lymphoma , lymphocytic lymphoma, intermediately differentiated mantle cell l.

large cell lymphoma  any of several types of lymphoma characterized by the formation of one or more types of malignant large lymphocytes, such as large cleaved or noncleaved follicular center cells, in a diffuse pattern.

large cell, immunoblastic lymphoma  a highly malignant type of non-Hodgkin's lymphoma characterized by large lymphoblasts (B or T lymphoblasts or a mixture) resembling histiocytes and having a diffuse pattern of infiltration.

Lennert's lymphoma  a type of non-Hodgkin's lymphoma with a high content of epithelioid histiocytes and frequently with bone marrow involvement.

lymphoblastic lymphoma  a highly malignant type of non-Hodgkin's lymphoma composed of a diffuse, relatively uniform proliferation of cells with round or convoluted nuclei and scanty cytoplasm.

malignant lymphoma  a group of malignancies characterized by the proliferation of cells native to the lymphoid tissues, i.e., lymphocytes, histiocytes, and their precursors and derivatives; the group is divided into two major clinicopathologic categories: Hodgkin's disease and non-Hodgkin's lymphoma.

mantle cell lymphoma , mantle zone lymphoma a rare form of non-Hodgkin's lymphoma having a usually diffuse pattern with both small lymphocytes and small cleaved cells.

marginal zone lymphoma  a group of related B-cell neoplasms that involve the lymphoid tissues in the marginal zone, the patchy area outside the follicular mantle zone.

mixed lymphocytic-histiocytic lymphoma  non-Hodgkin's lymphoma characterized by a mixed population of cells, the smaller cells resembling lymphocytes and the larger ones histiocytes.

nodular lymphoma  follicular l.

non-Hodgkin's lymphoma  a heterogeneous group of malignant lymphomas, the only common feature being an absence of the giant Reed-Sternberg cells characteristic of Hodgkin's disease.

plasmacytoid lymphocytic lymphoma  a rare variety of small lymphocytic lymphoma in which the predominant cell type is the plasma cell.

primary effusion lymphoma  a B-cell lymphoma associated with human herpesvirus 8 infection, characterized by the occurrence of lymphomatous effusions in body cavities without the presence of a solid tumor.

small B-cell lymphoma  the usual type of small lymphocytic lymphoma, having predominantly B lymphocytes.

small cleaved cell lymphoma  a group of non-Hodgkin's lymphomas characterized by the formation of malignant small cleaved follicular center cells, with either a follicular or diffuse pattern.

small lymphocytic lymphoma  a diffuse form of non-Hodgkin's lymphoma representing the neoplastic proliferation of well-differentiated B lymphocytes, with focal lymph node enlargement or generalized lymphadenopathy and splenomegaly.

small lymphocytic T-cell lymphoma  small lymphocytic lymphoma that has predominantly T lymphocytes.

small noncleaved cell lymphoma  a highly malignant type of non-Hodgkin's lymphoma characterized by the formation of small noncleaved follicular center cells, usually in a diffuse pattern.

T-cell lymphomas  a heterogeneous group of lymphoid neoplasms representing malignant transformation of the T lymphocytes.

U-cell lymphoma , undefined lymphoma a category of non-Hodgkin's lymphomas that cannot be classified into a definite type by either morphologic or known immunocytochemical markers.

undifferentiated lymphoma  small noncleaved cell l.

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giant follicular lymphoma,

a nodular, well-differentiated lymphocytic malignant lymphoma in which nodules distort the normal structure of a lymph node. Also called Brill-Symmers disease, giant follicular lymphadenopathy, Symmers' disease.

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lymphoma

any neoplastic disorder of lymphoid tissue. Often used to denote malignant lymphoma, classifications of which are based on predominant cell type and degree of differentiation; various categories may be subdivided into nodular and diffuse types, depending on the predominant pattern of cell arrangement. There is also a great deal of difference in the types of disease in the different animal species. There is a system of classification based on the histological characteristics of the lymphocytes.

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African lymphoma

see burkitt's lymphoma.

angiotropic large-cell lymphoma

an uncommon form of the disease seen rarely in dogs; lesions most commonly in the lungs producing a syndrome similar in many ways to congestive heart failure.

bovine malignant lymphoma

the tumor form of bovine viral leukosis.

Burkitt's lymphoma

see burkitt's lymphoma.

canine malignant lymphoma

the commonest hemopoietic neoplasm of dogs. It is characterized by lymphoid tumors in multiple lymph nodes, spleen, liver or other organs. Lymphocytic leukemia with involvement of bone marrow is much less common.

cutaneous lymphoma

round, raised cutaneous nodules or plaques caused by the infiltration of neoplastic lymphocytes with a tropism for epithelial cells. Occurs in cattle, dogs and humans. See also mycosis fungoides.

follicular lymphoma

a malignant lymphoma in which the lymphomatous cells are in clusters in the lymph node resembling follicles. Called also giant follicular lymphoma, nodular lymphoma.

giant follicular lymphoma

see follicular lymphoma (above).

Hodgkin's type lymphoma

rare, but reported most frequently in the dog. A diagnosis depends on the identification of the Reed-Sternberg cell in a mixed population of lymphocytes accompanied by sclerosis.

immunoblastic lymphoma

may be nonsecretory or may secrete immunoglobulins. See also myeloma.

large cell lymphoma

classified as diffuse, large cells, large cell immunoblastic or mixed tumors with large cells.

lymphoblastic lymphoma

tumors of medium-sized lymphocytes or small noncleaved lymphocytes.

malignant lymphoma (histiocytic)

a form in which the predominant cell is the prolymphocyte (reticulum cell).

malignant lymphoma (mixed cell)

a form containing proliferations of both prolymphocytes and lymphocytes.

malignant lymphoma (poorly differentiated lymphocytic)

a form in which the predominant cell is morphologically similar to the lymphoblast, containing a fine nuclear chromatin structure and one or more nucleoli.

malignant lymphoma (small cell lymphocytic, small cleaved cell, well-differentiated lymphocytic)

the form in which the predominant cell is the mature lymphocyte.

malignant lymphoma (undifferentiated)

a form in which relatively large stem cells with large nuclei, pale, scanty cytoplasm and indistinct borders predominate.

nodular lymphoma

see follicular lymphoma (above).

T cell lymphoma

a form in which the predominant cell is the mature lymphocyte.

thymic lymphoma

occurs most commonly in yearling cattle and cats. In cattle, it causes obstruction of the esophagus leading to ruminal tympany, engorgement of jugular veins and edema of brisket and submandibular space. In cats it is caused by feline leukemia virus infection and is usually associated with pleural effusion and accompanying dyspnea and regurgitation.