giant cell tumor of bone

giant cell tumor of bone

n.

A sometimes malignant osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells. It occurs most frequently in an end of a long tubular bone. Also called giant cell myeloma, osteoclastoma.

---

giant cell tumor of bone.

See giant cell myeloma.

---

giant cell tumor of bone

A lesion that comprises 5% of all osseous tumors, which is most common in the weight-bearing epiphysis of ♀ > age 20, which affects the distal femur, proximal tibia, distal radius; 60% recur with curettage; 10% metastasize, an event far more common in deep–to the fascial planes–tumors DiffDx A GCT-like histopathologic lesion may be seen in the brown tumor of hyperparathyroidism, chondroblastoma, giant cell reparative granuloma, benign and malignant fibrous histiocytoma, nonossifying and chondromyxoid fibroma, unicameral bone cyst, aneurysmal bone cyst, fibrous dysplasia, osteoblastoma, osteosarcoma, osteoid osteoma, eosinophilic granuloma