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giant cell reaction |
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giant cell reaction Any reparative tissue reaction with multinucleated epithelioid histiocytes, that may be due to exogenous material–eg, sutures, or endogenous material–eg, the contents of a ruptured epidermal inclusion cyst,
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Many cases initially diagnosed as giant cell MFH have been reclassified as giant cell-rich osteosarcoma, leiomyosarcoma with an osteoclastic giant cell reaction, or giant cell-rich anaplastic carcinoma. No recognizable myeloma casts or multinucleated giant cell reaction was seen in any of the cases. These changes included the presence of 1 or more of the following: granulation tissue, fat necrosis, inflammation, hemosiderin-laden macrophages, stromal and intraductal hemorrhage, and foreign-body giant cell reaction (Figures 1 and 3). |
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