giant cell myeloma


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myeloma

 [mi″ĕ-lo´mah]
1. a tumor composed of plasma cells of the type normally found in the bone marrow.
giant cell myeloma giant cell tumor (def. 1).
multiple myeloma see multiple myeloma.
plasma cell myeloma multiple myeloma.
solitary myeloma a variant of multiple myeloma in which there is a single localized tumor focus. Called also plasma cell tumor.

gi·ant cell tu·mor of bone

a soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells, occurring most frequently in an end of a long tubular bone of young adults.

giant cell myeloma

a bone tumor of multinucleated giant cells that resembles osteoclasts scattered in a matrix of spindle cells. Myelomas of this kind may be benign or malignant and may cause pain, functional disability, and pathological fractures. Also called giant cell tumor of bone.

gi·ant cell tu·mor of bone

(jī'ănt sel tū'mŏr bōn)
A soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells, occurring most frequently in an end of a long tubular bone of young adults.
Synonym(s): giant cell myeloma, osteoclastoma.

gi·ant cell tu·mor of bone

(jī'ănt sel tū'mŏr bōn)
A soft, reddish-brown, sometimes malignant, osteolytic tumor composed of multinucleated giant cells and ovoid or spindle-shaped cells; most frequent in young adults.
Synonym(s): osteoclastoma.

myeloma

1. a B lymphocyte tumor.
2. multiple myeloma.

giant cell myeloma
giant cell tumor (1).
multiple myeloma
a malignant neoplasm of plasma cells, in which the plasma cells proliferate and invade the bone marrow, causing destruction of the bone and resulting in pathological fracture and bone pain. A secretory form of the disease is characterized by the presence of an immunoglobulin recognized as Bence Jones protein (monoclonal immunoglobulin), Bence Jones proteinuria, anemia, and lowered resistance to infection. It is the most common type of monoclonal gammopathy. A non-secretory form of the disease also occurs.
osteosclerotic myeloma
multiple myeloma associated with osteosclerosis (rather than bone destruction) and often with peripheral neuropathy.
plasma cell myeloma
see multiple myeloma (above).
myeloma protein
the immunoglobulin molecules produced by myeloma cells. See gammopathy.
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