giant cell myeloma

myeloma /my·elo·ma/ (mi″ĕ-lo´mah) a tumor composed of cells of the type normally found in the bone marrow.

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giant cell myeloma  see under tumor (1).

multiple myeloma  a disseminated type of plasma cell dyscrasia characterized by multiple bone marrow tumor foci and secretion of an M component, manifested by skeletal destruction, pathologic fractures, bone pain, the presence of anomalous circulating immunoglobulins, Bence Jones proteinuria, and anemia.

plasma cell myeloma  multiple m.

sclerosing myeloma  myeloma associated with osteosclerosis, most often manifested by peripheral neuropathy.

solitary myeloma  a variant of multiple myeloma in which there is a single localized tumor focus.

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giant cell myeloma

n.

See giant cell tumor of bone.

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giant cell myeloma,

a bone tumor of multinucleated giant cells that resembles osteoclasts scattered in a matrix of spindle cells. Myelomas of this kind may be benign or malignant and may cause pain, functional disability, and pathologic fractures. Also called giant cell tumor of bone.

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myeloma

1. a B lymphocyte tumor.

2. multiple myeloma.

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giant cell myeloma

giant cell tumor (1).

multiple myeloma

a malignant neoplasm of plasma cells, in which the plasma cells proliferate and invade the bone marrow, causing destruction of the bone and resulting in pathological fracture and bone pain. A secretory form of the disease is characterized by the presence of an immunoglobulin recognized as Bence Jones protein (monoclonal immunoglobulin), Bence Jones proteinuria, anemia, and lowered resistance to infection. It is the most common type of monoclonal gammopathy. A non-secretory form of the disease also occurs.

osteosclerotic myeloma

multiple myeloma associated with osteosclerosis (rather than bone destruction) and often with peripheral neuropathy.

plasma cell myeloma

see multiple myeloma (above).

myeloma protein

the immunoglobulin molecules produced by myeloma cells. See gammopathy.