Giant cell hepatitis associated with direct Coombs' test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear.
Key words: Giant cell hepatitis, immune hemolytic anemia, direct Coombs' test, rituximab
Giant cell hepatitis (GCH) associated with direct Coombs' test-positive autoimmune hemolytic anemia (AIHA) is a rare, often lethal condition of early childhood with unknown pathogenesis.
Giant cell hepatitis (GCH) associated with AIHA has been reported to have mortality rates as high as approximately 50% (13), and this high mortality has been attributed not only to the severe liver failure or uncontrollable anemia, but also to sepsis related to the aggressive use of immunosuppressive drugs (6), (8), (13), (17).
Liver transplant for giant cell hepatitis with autoimmune hemolytic anemia.
Successful liver transplantation for giant cell hepatitis and Coombs-positive hemolytic anemia: a case report.
Alemtuzumab for giant cell hepatitis with autoimmune hemolytic anemia.