giant cell hepatitis


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ne·o·na·tal hep·a·ti·tis

hepatitis in the neonatal period presumed to be due to any of a variety of causes, chiefly viral; characterized by direct and indirect bilirubinemia, hepatocellular degeneration, and appearance of multinucleated giant cells; may be difficult to distinguish from biliary atresia, but is more likely to end with recovery, although cirrhosis may develop.

giant cell hepatitis

A nonspecific reaction of the newborn liver to increased conjugated hyperbilirubinemia, which occurs with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes simplex) and other in utero and neonatal infections (e.g., coxsackie, hepatitis, Escherichia coli infection, syphilis) and metabolic defects (e.g., a1-antitrypsin deficiency; cystic fibrosis; hereditary fructose intolerance; galactosemia; tyrosinosis requiring parenteral nutrition; choledocal cysts, idiopathic, congenital hepatic fibrosis, trisomy 18 and Byler’s, Lucey-Driscoll, Niemann-Pick and Zellweger’s diseases)

giant cell hepatitis

Giant cell transformation of liver Neonatology A nonspecific reaction of the newborn liver to ↑ conjugated hyperbilirubinemia; conjugated BR is ↑ in infants with intra- or extrahepatic biliary atresia, erythroblastosis fetalis, TORCH–toxoplasmosis, rubella, CMV, HS, and other in utero and neonatal infections–eg, coxsackie, hepatitis, E coli, syphilis, metabolic defects–eg, α1-antitrypsin deficiency, cystic fibrosis, hereditary fructose intolerance, galactosemia, parenteral nutrition and tyrosinosis, choledocal cysts, idiopathic, congenital hepatic fibrosis, Byler's disease, Lucy-Driscoll disease, Niemann-Pick disease, trisomy 18, and Zellweger's disease. Cf Syncytial giant cell hepatitis.
References in periodicals archive ?
Giant cell hepatitis associated with direct Coombs' test-positive hemolytic anemia is a rare condition of childhood and the pathogenesis remains unclear.
Key words: Giant cell hepatitis, immune hemolytic anemia, direct Coombs' test, rituximab
Giant cell hepatitis (GCH) associated with direct Coombs' test-positive autoimmune hemolytic anemia (AIHA) is a rare, often lethal condition of early childhood with unknown pathogenesis.
Giant cell hepatitis (GCH) associated with AIHA has been reported to have mortality rates as high as approximately 50% (13), and this high mortality has been attributed not only to the severe liver failure or uncontrollable anemia, but also to sepsis related to the aggressive use of immunosuppressive drugs (6), (8), (13), (17).
Liver transplant for giant cell hepatitis with autoimmune hemolytic anemia.
Successful liver transplantation for giant cell hepatitis and Coombs-positive hemolytic anemia: a case report.
Alemtuzumab for giant cell hepatitis with autoimmune hemolytic anemia.
Liver histology showed, among other features, a giant cell hepatitis which has not yet been described for drug-induced liver disease (Zimmerman, 1999).
A case of syncytial giant cell hepatitis with features of a paramyxoviral infection.
Then doctors discovered Rachel had giant cell hepatitis, a rare but still treatable type of hepatitis.
On Christmas Eve, Charlie was diagnosed as having giant cell hepatitis - the same as me.
This leaves a large group of infants with what is called IDIOPATHIC NEONATAL HEPATITIS, Giant Cell Hepatitis or familial Cholestatis.

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