giant cell fibroma


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gi·ant cell fi·bro·ma

a tumor of the oral mucosa composed of fibrous connective tissue with large stellate and multinucleate fibroblasts; shares a similar histology with the retrocuspid papilla, fibrous papule of the nose, pearly penile papule, and the ungual fibroma.
The oral counterpart of fibrous papule of the nose, which appears as an asymptomatic sessile or pedunculated nodule measuring less than 1 cm in diameter. Often, it has a bosselated or somewhat papillary surface. Most cases occur in ages 10-30 years. No sex predilection has been reported. The most common sites are the mandibular gingiva, followed by maxillary gingiva, tongue and palate.
DiffDx Squamous papilloma, irritation fibroma, pyogenic granuloma, and peripheral giant cell granuloma
Management Conservative excisional biopsy is curative, and its findings are diagnostic. Recurrence is rare

gi·ant cell fi·bro·ma

(jī'ănt sel fī-brō'mă)
A tumor of the oral mucosa composed of fibrous connective tissue with large stellate and multinucleate fibroblasts.
Compare: giant cell granuloma

gi·ant cell fi·bro·ma

(jī'ănt sel fī-brō'mă)
Tumor of oral mucosa composed of fibrous connective tissue with large stellate and multinucleate fibroblasts.
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References in periodicals archive ?
PCNA and Ki-67 immunoreactivity in multinucleated cells of giant cell fibroma and peripheral giant cell granuloma.
This article reviews three of these hyperplastic lesions: the irritation fibroma, the giant cell fibroma and the peripheral ossifying fibroma.
1), (3) Unlike the irritation fibroma, giant cell fibroma is not believed to result from chronic irritation but is simply a reactive lesion from some type of stimulus.
Surgical excision is again the recommended treatment for giant cell fibroma.
Clinically distinct but microscopically similar to the giant cell fibroma is the retrocuspid papilla.
Several fibrous hyperplastic lesions can be considered in the differential diagnosis of giant cell fibroma.
Keywords: Fibrous hyperplasias, giant cell fibroma, oral lesions
Until the early 1970s, the giant cell fibroma (GCF) was one among this group of similar lesions referred to as fibrous hyperplasias, fibroepithelial polyps, or, simply, fibromas.
Ultrastructure of the giant cell fibroma of the oral mucosa.
INTRODUCTION: The localized lesions of the oral cavity have been broadly documented as: Irritation fibroma, Peripheral ossifying fibroma, squamous papilloma, Giant cell fibroma, Pyogenic granuloma and Peripheral giant cell granuloma.
To retrieve biopsy cases of RCP in the LSUSD Department of Oral and Maxillofacial Pathology, the authors reviewed the pathology reports of all accessions coded as fibroma, irritation fibroma, traumatic fibroma, fibrous nodule, focal fibrous hyperplasia, and giant cell fibroma of the mandibular gingiva from January 1, 1990 to December 31, 2001.
14,15) It appears that many RCPs are microscopically similar to the giant cell fibroma.