giant cell


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Related to giant cell: giant cell tumor of tendon sheath, giant cell tumor, giant cell myocarditis, giant cell granuloma, giant cell arteritis, foreign body giant cell

gi·ant cell

a cell of large size, often with many nuclei.

giant cell

[jī′ənt]
Etymology: L, gigas, huge, cella, storeroom
an abnormally large tissue cell that often contains more than one nucleus and may appear as a merger of several normal cells.
Any markedly enlarged cell seen in benign or malignant lesions; while giant cells are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid giant cells of Langhans and Touton are associated with infections and other ‘benign’ processes—e.g., sarcoidosis—have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; giant cells in tumours are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers—e.g., bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active

giant cell

Any markedly enlarged cell seen in benign or malignant lesions; although GCs are highly nonspecific, their presence in the proper setting supports the diagnosis of certain diseases; the epithelioid GCs of Langerhans and Touton are associated with infections and other 'benign' processes–eg, sarcoidosis, have abundant cytoplasm and a rim or clutch of enlarged histiocyte-like nuclei; GCs in tumors are less inhibited by rules of cytologic etiquette and are anointed with adjectival modifiers–eg, bizarre, monster, osteoclastoma-like, Reed-Sternberg; the cell may be markedly enlarged and mitotically active.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.

giant cell

A large multinucleate cell formed from the fusion of many MACROPHAGES. Giant cells are often a feature of granulomas.

gi·ant cell

(jī'ănt sel)
A cell of large size, often with many nuclei.

giant cell,

n an abnormally large tissue cell. It often contains more than one nucleus and may appear as a merger of several normal cells.

giant cell

1. very large cells in normal tissue, e.g. megakaryocytes in bone marrow.
2. multinucleate macrophages found around foreign bodies and in granulomas. Three variants of multinucleated giant cells are recognized—Langhans, Touton and foreign body. Differentiation is based on the distribution of their nuclei.

giant cell epulis
peripheral giant cell granulomas appearing as bright red, smooth gingival masses in cats and dogs; includes hyperplastic epithelium and many giant cells in densely cellular stroma.
extraskeletal giant cell tumor
see malignant fibrous histiocytoma.
epidermal multinucleated giant cell
found in viral infections and chronic, pruritic dermatoses characterized by epidermal hyperplasia or dyskeratosis.
References in periodicals archive ?
A rare, potentially destructive tumor of the joint or tendon sheath, tenosynovial giant cell tumor (TGCT) can lead to significant pain, joint destruction, frequent surgery and loss of mobility
Hybrid central odontogenic fibroma with giant cell granuloma-like component: case report and review.
Histological analysis of intra-operative samples confirmed the presence of a giant cell tumour within a lipoma.
Following biopsy, pathology initially reported a mesenchymal spindle cell tumor with bone and numerous osteoclast-like giant cells.
Key Words: giant cell arteritis, multiple myeloma, monoclonal gammapathy, PET scan, anemia
4) However, these investigators did not report any cases involving the Achilles bursae, and stressed the need to differentiate extraskeletal soft-tissue chondromas from soft synovial bursae and tenosynovial chondromatosis, giant cell tumors of the tendon sheath, myxomas, and chondrosarcomas.
Giant cell arteritis, a necrotizing, granulomatous arteritis that is rarely seen before age 50, also should be considered.
Systemic signs or symptoms could suggest a metabolic or systemic inflammatory disease, such as giant cell arteritis.
Giant cell tumor-like lesion of the urinary bladder: A report of two cases and literature review; giant cell tumor or undifferentiated carcinoma?
Daiichi Sankyo Company, Limited (hereafter, Daiichi Sankyo), today announced that it has filed an application for approval in Japan to manufacture and market RANMARK (subcutaneous injection 120 mg) (INN: Denosumab (genetic recombination)), a gene recombinant drug to treat giant cell tumor of bone(hereafter, GCTB).
denosumab) in adults and skeletally mature adolescents diagnosed with giant cell tumor of bone (GCTB).