ghrelin


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Related to ghrelin: PYY

ghrel·in

(grel'in),
A naturally occurring 28-amino acid gut-brain growth hormone releasing peptide (GHRP) that is expressed mainly in the stomach and possibly in the hypothalamus. Fasting and hypoglycemia increase ghrelin levels and circulating ghrelin levels are decreased in chronic obesity, following acute caloric intake and in states of positive energy balance. Acute administration of ghrelin to humans induces a feeling of hunger. Ghrelin binds to ghrelin-receptors in the anterior pituitary and possibly in the mediobasal and mediolateral hypothalamus to stimulate growth hormone release and to regulate energy homeostasis. Serum levels of ghrelin are measurably higher in patients who have lost weight through dietary measures.
[growth hormone release + -in]

ghrelin

(grĕl′ən)
n.
A hormone that is secreted by cells in the stomach and promotes hunger before an expected meal, decreases in amount after eating, and promotes secretion of growth hormone.

ghrel·in

(grel'in)
A peptide hormone secreted by endocrine cells in the gastrointestinal tract. Acts as a growth hormone secretagogue and as an orexigenic agent mediated by the hypothalamic hormones neuropeptide Y (NPY) and agouti growth-related peptide (AGRP).
[growth hormone release + -in]

ghrelin

A 28-amino acid peptide hormone that stimulates release of growth hormone from the anterior pituitary and has significant effects on appetite and energy balance. The main source of ghrelin is the epithelial cells of the fundus of the empty stomach. Recent studies have shown that, in mice, the hormone also interacts with the hippocampus and appears to improve memory and cognitive function.

Ghrelin

A recently discovered peptide hormone secreted by cells in the lining of the stomach. Ghrelin is important in appetite regulation and maintaining the body's energy balance.
Mentioned in: Obesity
References in periodicals archive ?
The mean plasma concentration of ghrelin in the group with acute CD (748.
Usually ghrelin production goes up when the body is deprived of food.
Fasting blood was drawn to measure ghrelin, leptin, estradiol, testosterone, and follicle-stimulating hormone levels.
Unlike ghrelin though, RC-1291 can be administered as an oral treatment.
During periods of weight loss, the body produces high levels of ghrelin to slow down fat metabolism, encourage eating and promote fat retention.
Ghrelin improves performance by 30 to 40 per cent and encourages better-developed brain structure with around 30 per cent more brain cell connections.
19) reported a decline in ghrelin levels significantly after exercise in elite athletes and healthy subjects (age 18-37 yr).
Ghrelin is made in the stomach and controls hunger hour to hour.
Ghrelin was first discovered as an endogenous ligand for growth hormone secreting receptor (GHSR) (Kojima et al.
Because the hormone ghrelin has been shown to make animals eat more, the researchers reasoned that blocking the molecule's activity might reduce appetite and help animals and people lose weight.