The patent includes claims to the use of the Company's drug candidate, Trimesta(TM) (oral estriol), in conjunction with a gestagen
for the treatment of multiple sclerosis (MS) and other autoimmune diseases.
In order to avoid confounding effects of different gestagens
, Activelle, a low-dose oral hormone preparation containing the same gestagen
, was preferred.
The endometrial response to LNG-IUS had been reported as gestagen
induced endometrium or atrophic endometrium.
Melengestrol acetate (MGA), an orally active gestagen
, can be used for estrus synchronization and/or induction in cattle (11).
A randomized study on the effects of estrogen/ gestagen
or high dose oral calcium on trabecular bone remodeling in postmenopausal osteoporosis.
Use of an oestrogen, androgen or gestagen
as a potential chemesterilant for control of rat and mouse populations.
In contrast, no corresponding large difference in the cortisol values was observed between the EELEV and EEDES women, confirming the results from previous studies, in which different kinds of gestagens
were found to have similar effects on the liver synthesis of cortisol-binding globulin, which seems to be stimulated by the oral EE therapy (24-26).