gerontogen

gerontogen

[jeron′təjən]
an environmental agent that contributes to the aging process by accelerating the onset and/or rate of progression of aging. Examples include age-dependent cellular and biochemical responses to oxidant damage to aging of cells that have an intrinsic sensitivity to certain toxins and to toxic doses that are more likely to cause adverse effects on aging organisms.

ger·on·to·gen

(jer-on'tō-jen)
Agent that causes aging, especially premature aging (e.g., tobacco smoke).
References in periodicals archive ?
UV radiation from the sun makes us older too, and Sharpless and his colleagues recently showed that chemotherapy treatment is also a strong gerontogen.
From a public health perspective, cigarette smoke is likely the most important gerontogen, Sharpless said.
Sharpless said they believe just as an understanding of carcinogens has informed cancer biology, so will an understanding of gerontogens benefit the study of aging and by identifying and avoiding gerontogens, they will be able to influence aging and life expectancy at a public health level.
Potential gerontogens include benzene, arsenic, ultraviolet light, ionizing radiation, chemotherapy, psychological stress, and cigarette smoke.
Sharpless and colleagues predict the development of blood tests to evaluate a number of molecular age biomarkers in order to understand individual differences in the rate of aging and to assess the age-promoting effect of gerontogens.
Editor's Note: "We believe just as an understanding of carcinogens has informed cancer biology, so will an understanding of gerontogens benefit the study of aging," Dr.
ISLAMABAD -- Just as exposure to carcinogens increases a person's risk for cancer, experts now believe in a new research that class of environmental toxins -known as gerontogens - may put people at an increased risk for accelerated aging.
Toxins present in cigarette smoke, UV rays and chemotherapy are all suspected gerontogens - capable of accelerating the rate at which a person ages, Fox News reports.
In their study, Sharpless and his colleagues developed a system that allowed them to expose mice to certain gerontogens and then measure the accumulation of senescence cells in their bodies.