germfree


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germfree

(jûrm′frē′)
adj.
Free of microorganisms.

gnotobiotic

Biology
adjective Referring to a system to which only preselected components, organisms and nutrients are introduced. Gnotobiotic organisms are either experimental models (e.g., mice with naïve immune systems), or “experiments of nature”, in which the natural immune defence is grossly defective (e.g., severe combined immune deficiency); prolonged survival of the host requires complete avoidance of exposure to pathogens.
References in periodicals archive ?
Normal mice have Paneth cells with apical secretory granules by postnatal day seven (P7) and lysomzyme by P 10, but a delay in maturation is seen in germfree mice in whom lysozyme becomes detectable only by P148.
1981) Gnotobiology research in Japan--A brief history of and a review of the present status--, In Recent Advances in Germfree Research (eds.
In contrast, following the colonization with microbiota from conventionally raised mice, the body fat content in the originally germfree mice increased up to 60% in 14 days.
Biotransformation of inorganic arsenic in germfree and conventional mice.
840 Case Western Reserve University 541 School of Medicine Innovations Coldstream Laboratories 730 Contract Pharma 1526 Cook Pharmlca 734 GCT 5019 Germfree Laboratories 640 GlaxoSmithKline Biopharmaceuticals 349 HIQScreen 739 Institute of Industrial Organic 735 Chemistry Branch Pszczyna Jubilant HolllsterStier 637 KBI Blopharma, Inc.
Seth is undergoing treatment in Newcastle's Royal Victoria Inrmary's germfree Bubble Unit while he prepares for the operation that doctors hope will kick start his immune system.
Returning gut bacteria to germfree mice re-created normal caution in their offspring.
Stimulation of mice by bacterial antigens can be prevented by raising them germfree and feeding them a chemically-defined, ultra-filtered diet (GF-CD).
Sufferers are increasing at the rate of 5% a year, with some experts linking the rise to pollution or people living in a cleaner, germfree environment.
Few studies have evaluated the accuracy of NIFT in gnotobiotic piglets in portable germfree facilities, although several studies have described its use in mammals (Loughmiller et al.
Effects of 2,3,7,8-TCDD or 2,2',4,4',5,5'-HxCB on vitamin K dependent blood coagulation factors in male and female germfree WAG/RIJ-rats.