germ line


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Related to germ line: germ layer, Germline mutation

germ line

a collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

genetic material in a cell lineage that is passed down through the gametes before it is modified by somatic recombination or maturation.

germ line

(jĕrm līn)
A collection of haploid cells derived from the specialized cells of the primitive gonad.

germ line

1. The lineage of cells leading to the contemporary GERM CELLS.
2. Often used loosely to refer to the cells of the ovary and testes that give rise, respectively, to the ova and spermatozoa, and to the ova and spermatozoa themselves.

germ line

a group of cells that give rise to the GONADS, becoming differentiated from the ‘somatic’ cells early in embryonic development. Only germ-line cells have the potential to undergo MEIOSIS, and a MUTATION event in these cells may well be transmitted to the offspring, unlike genetic change in somatic cells (see SOMATIC MUTATION).

germ

1. old-fashioned and lay term for a pathogenic microorganism.
2. living substance capable of developing into an organ, part or organism as a whole; a primordium. Commonly used to refer to the embryos of wheat grains which are removed during milling and sold separately as wheat germ.

germ cell
direct descendants of the primordial cells which originate from the yolk sac endoderm and migrate to the gonadal ridges of the embryo, where they give rise to either ova or spermatozoa. Called also gonocytes, sex cells.
germ cell tumor
a rare tumor in dogs, similar to more common lesions in humans. Similar to pituitary adenomas in distribution and cellular characteristics.
germ line
the genetic material as it is transferred via the gametes, before being modified by somatic recombination or mutation.
germ line cells
gametes.
germ line transmission
a mode of transmission, particularly of retroviruses, whereby the genome of the virus is integrated into the chromosomal DNA and transmitted via gametes to offspring.
germ plasma evaluation program
a planned investigative, large scale breeding program aimed at accumulating comparative information on the relative performance of various breeds and crossbreeds of agricultural animals.
germ theory
1. all organisms are developed from a cell.
2. infectious diseases are of microbial origin.
germ tube
a tube-like structure that develops during the growth of some fungi and becomes a hypha; a feature of the yeast, Candida albicans.
wheat germ
see wheat germ.
References in periodicals archive ?
The application of adult somatic cell alteration, germ line manipulation, and/or human cloning--either alone or in combination--could result in adverse physical consequences to the offspring.
21) At a meeting attended primarily by scientists to discuss germ line therapy and possible guidelines for its implementation, James Watson suggested that a serious candidate for a disease to be cured by germ line therapy was stupidity (Gina Kolata, "Scientists Brace for Changes in Path of Human Evolution," New York Times, 21 March 1998, A1 and A7).
Friedmann, Approaches to Gene Transfer to the Mammalian Germ Line, in Designing Our Descendants: The Promises and Perils of Genetic Modifications, ed.
supra note 6, at 1145-47 (noting that the ability of human embyonic stem cells to "contribute to the germ line in chimeras is not a testable property").
While there is no theoretical reason for not using germ line gene therapy, there is a persuasive argument which concludes that all forms of germ line genetic engineering involving humans should be prohibited.
It also tries to collect and understand the reasons that could be put forward for and against germ line therapy and genetic enhancement.
These are spontaneous mutations in the germ line, and they just stay there," he says.
acknowledge that ES cells provide "a powerful approach for introducing specific genetic changes into the mouse germ line.
These iPS cells also showed superior ability for contribution and transmission through the germ line, which is one of the critical criteria for assessing the quality of iPS cells.
This achievement opens a wide vista of possibilities of introducing and testing foreign DNA sequences in the mosquito germ line for both basic research and the development of a wide array of biological control methods," note Margaret G.
Wilson (director of the Institute for Human Gene Therapy, University of Pennsylvania), suggested that we can no longer take comfort in the belief that, for example, manipulation of the germ line poses too many technical problems to be feasible and that thus questions about its sale are moot.