geriatric dosing

geriatric dosing

In a person older than 65, any adjustment in the strength and/or the frequency of drug administration designed to minimize the risk of adverse drug reactions. Older patients should typically begin a new drug regimen by taking a smaller dose of a pharmaceutical agent than younger individuals.

CAUTION!

In general, older people metabolize drugs more slowly than younger ones. Slower metabolism may produce higher drug concentrations or longer half-lives. In addition older people often excrete drugs more slowly than the young. Subtle impairments in kidney or liver function that occur with aging often combine to increase the risk of drug toxicity. Drugs that frequently impair thinking in the elderly include sedatives, hypnotics, analgesics, anticholinergics, and psychotropic medications. NSAIDs and anticoagulants are more likely to cause bleeding in older people than younger ones; NSAIDs also pose an increased risk of kidney failure in the elderly. This brief list of potential pharmaceutical problems in the elderly is not meant to be comprehensive. Before administering any drug to an older patient, it is prudent to assess the proposed benefits of the treatment relative to known risks.
References in periodicals archive ?
In addition to drug allergies, a good computerized prescribing system should also alert physicians to drug-drug interactions, renal dosing issues, geriatric dosing issues, and dose ceilings, according to Dr.
The A-B rated authorized generic of oxandrolone tablets will continue to meet all quality control standards of the Oxandrin([R]) brand, will contain the same active and inactive pharmaceutical ingredients and will contain in its labeling the geriatric dosing regime for which Savient has been granted exclusivity by the FDA.
NASDAQ: SVNTE) an emerging specialty pharmaceuticals company focused on developing, manufacturing and marketing novel therapeutic products for unmet medical needs, today announced it has filed a Citizens' Petition with the United States Food and Drug Administration (FDA) requesting that the Commissioner of Food and Drugs not approve any Abbreviated New Drug Application (ANDA) for generic oral products containing oxandrolone prior to the expiration of the Company's exclusive labeling for geriatric dosing on June 20, 2008.
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