gentamicin


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Related to gentamicin: vancomycin

gentamicin

 [jen″tah-mi´sin]
an aminoglycosideantibiotic complex elaborated by bacteria of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus; used as the sulfate salt.

gen·ta·mi·cin

(jen'tă-mī'sin), Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, obtained from Micromonospora purpurea and M. echinospora, which inhibits the growth of both gram-positive and gram-negative bacteria; the sulfate salt is used medicinally.

gentamicin

/gen·ta·mi·cin/ (jen″tah-mi´sin) an aminoglycoside antibiotic complex isolated from bacteria of the genus Micromonospora, effective against many gram-negative bacteria as well as certain gram-positive species; used as the sulfate salt.

gentamicin

(jĕn′tə-mī′sĭn)
n.
A broad-spectrum antibiotic derived from an actinomycete of the genus Micromonospora, used in its sulfate form to treat various infections.

gentamicin

Garamycin® Infectious disease A broad-spectrum aminoglycoside antibiotic obtained from Micromonospora purpurea Adverse effects Ototoxicity, nephrotoxicity Therapeutic range Peak 5-10 mg/L; trough < 2 mg/L Toxic range Peak > 10 mg/L; trough > 2 mg/L. See Aminoglycosides.

gen·ta·mi·cin

(jen'tă-mī'sin) Avoid the misspelling gentamycin.
A broad spectrum antibiotic of the aminoglycoside class, which inhibits growth of both gram-positive and gram-negative bacteria; sulfate salt is also used medicinally.

gentamicin

An aminoglycoside antibiotic used mainly for the treatment of serious GRAM NEGATIVE infections. Otherwise, gentamicin is used topically for external infections, such as those of the eye or ear. In large dosage it can cause TINNITUS, deafness and kidney damage. Recently, gentamycin has been shown to be capable of bypassing a STOP MUTATION and has been shown to be helpful in controlling CYSTIC FIBROSIS and other genetic disorders caused by stop mutations. The drug is on the WHO official list. Brand names are Cidomycin, Garamycin, Genticin and Minims gentamicin. See also PTC124.

gentamicin

broad-spectrum, aminoglycoside antibiotic; inhibits some Gram-positive, most Gram-negative bacteria and also Pseudomonas aeruginosa ; largely ineffective against anaerobes and haemolytic streptococci; given by injection for severe infections; side-effects include ototoxicity and nephrotoxicity, especially in the elderly

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

gen·ta·mi·cin

(jen'tă-mī'sin)
Broad spectrum aminoglycoside antibiotic that inhibits growth of both gram-positive and gram-negative bacteria.

gentamicin, gentamycin

an antibiotic complex elaborated by fungi of the genus Micromonospora, effective against many gram-negative bacteria, especially Pseudomonas species, as well as certain gram-positive bacteria, especially Staphylococcus aureus. As with other aminoglycoside antibiotics gentamicin is ototoxic and nephrotoxic. Used as the sulfate.
References in periodicals archive ?
At the second post-treatment audiometry, a reversal of hearing loss was seen in 3 of the 29 gentamicin patients (10.
12,13) However, unlike these studies, the rate of gentamicin resistance in children in our study was higher than that in adults.
In both apramycin resistant isolates, resistance was found to gentamicin and tobramycin, medically important antibiotics.
She saw him walk and she told us she thought he walked like her son, who was given gentamicin," Mr.
Key words: biomarkers, cisplatin, gentamicin, microarrays, nephrotoxicity, proximal tubule, puromycin, toxicogenomics.
THE injectable form of gentamicin is usually reserved for treatment of very serious, complicated infections in hospital.
Keeping the above points in view, we modified surface properties of coralline hydroxyapatite (CHA), derived from Indian coral, by grafting with glycidylmethacrylate (GMA) using redox initiators and subsequently coupled with gentamicin and characterized for drug loading and in-vitro release characteristics.
The IV gentamicin and ampicillin was started but was run in half the usual time, because "we are behind schedule.
Suppose a 61-year-old woman hospitalized for bacterial pneumonia begins a standard intravenous gentamicin dose of 60 mg every eight hours.
Providing an alternate gentamicin formulation, without preservatives, was an unmet need Fera was glad to fill.