Nevertheless in the study cited above (1) the intensity of exposure to genotoxins
from polluted air was able to induce chromosomal damage more efficiently than tobacco smoke.
A certain structural change called adducts can occur in the DNA of spermatogenic cells in response to genotoxins
But a 2001 study at the University of Pennsylvania suggested that the vitamin also contributed to the production of different fat-derived toxins that attack DNA, sometimes called genotoxins
, which are implicated in cancer.
Since the risk of mitotic errors is proportional to cellular mitotic activity, X monosomy may be secondary to increased mitotic activity after exposure to chemical and physical genotoxins
, which are known to cause chromosomal loss in blood cells, or to an inherited genetic trait," the researchers said.
The new research shows vitamin C is capable of inducing the production of DNA-damaging chemical agents called genotoxins
Airborne PCBs are more readily metabolized and therefore are not generally found in biological samples, but can result in bioactivated intermediates that act as genotoxins
, mutagens, and carcinogens.
The second option does not require in vitro mammalian testing, but clearly does not prevent the use of existing or alternative methods to screen out genotoxins
missed by the Ames test.
While it is possible that these lipids may be converted to genotoxins
, which in turn may damage DNA, it is far from conclusive that this is a cancer-causing mechanism.
The increased vu1nerability of the developing fetus and child to genotoxins
and carcinogens has been widely recognized.
Vitamin C-induced decomposition of lipid hydroperoxides to endogenous genotoxins
Transplacental transfer of genotoxins
and transplacental carcinogenesis.
Pesticide formulations have proven to be more potent genotoxins
than active ingredients alone in a variety of test systems.