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genotoxic
(redirected from genotoxin)

    Also found in: Dictionary/thesaurus, Wikipedia 0.01 sec.
genotoxic /ge·no·tox·ic/ (je´no-tok″sik) damaging to DNA: pertaining to agents known to damage DNA, thereby causing mutations, which can result in cancer.
ge·no·tox·ic (jn-tksk)
adj.
Damaging to DNA and thereby capable of causing mutations or cancer.
genotoxic
[jē′nōtok′sik]
capable of altering DNA, thereby causing cancer or mutation.
genotoxic [je´no-tok″sik]
damaging to DNA; pertaining to agents (radiation or chemical substances) known to damage DNA, thereby causing mutations or cancer.
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It thus has the potential to be a useful laboratory reagent for studying the role of hPNKP in the cellular response to ionizing radiation and other genotoxins, and act as the initial compound in the development of a drug targeting hPNKP in the course of cancer therapy.
Identification of a Small Molecule Inhibitor of the Human DNA Repair ... by Feridoun Karimi-Busheri / Biological sciences community
The second option does not require in vitro mammalian testing, but clearly does not prevent the use of existing or alternative methods to screen out genotoxins missed by the Ames test.
Preventing late stage failure due to genotoxic liabilities: speaking ... by Tweats, David; Walmsley, Richard / Pharma
Pesticide formulations have proven to be more potent genotoxins than active ingredients alone in a variety of test systems.
Unidentified inert ingredients in pesticides: implications for human ... by Surgan, Michael / Environmental Health Perspectives
 
 
 
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