genotoxic damage

genotoxic damage

Injury to the chromosomes of the cells. This may be determined by noting the number of micronuclei in the target tissues. When a cell with damaged genetic material divides, fragments of chromosomes and micronuclei remain in the cytoplasm.
References in periodicals archive ?
2]) at the residential addresses of a sample of the previously investigated children, to test whether exposure to these pollutants was associated with evidence of genotoxic damage, assessed by the alkaline comet and micronucleus assays (Dhillon et al.
GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage.
Spanish genetic toxicologist Blanca Laffon and colleagues are conducting the only long-term study of genotoxic damage and endocrine alterations due to a major oil spill.
Some organisms such as plants, fish, birds and frogs were also investigated by micronucleus test to detect environmental pollution capable of producing genotoxic damage [15-18].
Though exact mechanism of action of Andrographis extract is not known, however, based on the above reports it is plausible that scavenging of free radicals and hydrogen transfer by andrographolide might play an important role in providing protection against arsenic-induced oxidative and genotoxic damage as evident from this study.
In this context the natural antioxidants/ plant products may provide protection against the genotoxic damage of synthetic steroids, thereby decreasing the possibility of carcinogenesis in the frequent use s of synthetic steroids or contraceptives [19,23,21,18,20].
The volunteers in the trial's synbiotic group showed significantlydecreased genotoxic damage, that is damage to the cells' DNA, compared with those who consumed the placebo.
In addition, variation in effects according to clone-specific deficiencies in DNA repair pathways can be used to investigate the specific type(s) of genotoxic damage produced by a given chemical.
The multistage cancer may be due to the initial uptake of a carcinogen and subsequent stable genotoxic damage caused by its metabolic activation [2].
A dramatic increase in genotoxic damage was noticed when the dosage was increased to 40 and 60 mM.