genotoxic damage

genotoxic damage

Injury to the chromosomes of the cells. This may be determined by noting the number of micronuclei in the target tissues. When a cell with damaged genetic material divides, fragments of chromosomes and micronuclei remain in the cytoplasm.
References in periodicals archive ?
Standardization of counting micronuclei: definition of a protocol to measure genotoxic damage in human exfoliated cells.
MMS, an alkylating agent, is known for its ability to interact with DNA in vitro and in vivo producing genotoxic damage.
vulgaris and its primary synthetic constituent thymol against UVA- and UVB-induced oxidative and genotoxic damage in the keratinocyte cell line NCTC 2544.
Genotoxic damage in Solea senegalensis exposed to sediments from the Sado Estuary (Portugal): effects of metallic and organic contaminants.
The pre-treatment protocol allows the evaluation of capability to prevent the mutagen induced genotoxic damage, while the post-treatment protocol gives information about the capability of the test compound to repair mutagen-induced damage.
extract against cyproterone acetate induced genotoxic damage in cultured human lymphocytes.
Inzunza B, Orrego R, Penalosa M, Gavilan JF, Barra R (2006) Analysis of CYP4501A1, PAHs metabolites in bile, and genotoxic damage in Oncorhynchus mykiss exposed to Biobio River sediments, Central Chile.
Is the capacity of lead acetate and cadmium chloride to induce genotoxic damage due to direct DNA-metal interaction Mutagenesis 16: 265270.
7,13) The micronucleus assay has been used to assess the genotoxic damage in oral squamous cell carcinoma and oral premalignancies.
2]) at the residential addresses of a sample of the previously investigated children, to test whether exposure to these pollutants was associated with evidence of genotoxic damage, assessed by the alkaline comet and micronucleus assays (Dhillon et al.