2]) at the residential addresses of a sample of the previously investigated children, to test whether exposure to these pollutants was associated with evidence of genotoxic damage
, assessed by the alkaline comet and micronucleus assays (Dhillon et al.
4 mg is shown) did not produce visible genotoxic damage
GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage
Spanish genetic toxicologist Blanca Laffon and colleagues are conducting the only long-term study of genotoxic damage
and endocrine alterations due to a major oil spill.
Some organisms such as plants, fish, birds and frogs were also investigated by micronucleus test to detect environmental pollution capable of producing genotoxic damage
Though exact mechanism of action of Andrographis extract is not known, however, based on the above reports it is plausible that scavenging of free radicals and hydrogen transfer by andrographolide might play an important role in providing protection against arsenic-induced oxidative and genotoxic damage
as evident from this study.
In these cells the inability to respond correctly to DNA damage leads to increased cytotoxicity of genotoxins, and aberrant genotoxic damage
at high concentrations of non-genotoxic cytotoxins.
In this context the natural antioxidants/ plant products may provide protection against the genotoxic damage
of synthetic steroids, thereby decreasing the possibility of carcinogenesis in the frequent use s of synthetic steroids or contraceptives [19,23,21,18,20].
The volunteers in the trial's synbiotic group showed significantlydecreased genotoxic damage
, that is damage to the cells' DNA, compared with those who consumed the placebo.
In addition, variation in effects according to clone-specific deficiencies in DNA repair pathways can be used to investigate the specific type(s) of genotoxic damage
produced by a given chemical.
The multistage cancer may be due to the initial uptake of a carcinogen and subsequent stable genotoxic damage
caused by its metabolic activation .
A dramatic increase in genotoxic damage
was noticed when the dosage was increased to 40 and 60 mM.