From there, specific types of dose--response relationship, such as the sometimes controversial hormesis mechanism and always controversial biological thresholds for genotoxic carcinogens
, are discussed, thereby supplementing the understanding of these latter critical concepts.
Although the in vitro test battery demonstrates a high degree of sensitivity in detecting genotoxic carcinogens
, it is poor at correctly identifying noncarcinogens.
The experts also said fires at the works were also a source of genotoxic carcinogens
The ready quantifiable nature of sister chromatid exchanges with high sensitivity for revealing toxicant-DNA interaction and the demonstrated ability of genotoxic chemicals to induce significant increase in sister chromatid exchanges in cultured cells has resulted this endpoint being used as indicator of DNA damage in blood lymphocytes of individuals exposed to genotoxic carcinogens
Often being found in baked, fried or grilled foods, acrylamide is a suspected carcinogen and the UK Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment states that exposure to genotoxic carcinogens
should be as low as reasonably possible.
However, in the present study, which was shorter term and used a lower dose, we found no change in oxidative DNA-damage-related gene expression, nor did we find a gene expression profile characteristic of a range of genotoxic carcinogens
, such as described by Ellinger-Ziegelbauer et al.
At least," he says, "there is a contrast with tobacco smoke, where genotoxic carcinogens
are clearly present and involved along with other types of effects, and carcinogen-DNA adducts have been observed in the breast tissue of exposed women.
The frequency of chromosomal aberrations (CAs) in human peripheral blood lymphocytes (PBLs) measured with the conventional cytogenetic assay in metaphase cells has routinely been used for several decades as a tool to monitor occupational and environmental exposures to genotoxic carcinogens
These tumors are readily induced by many genotoxic carcinogens
, but they may also be induced by virtually any nongenotoxic goitrogen in these rodent species.
Rapid induction of more malignant tumors by various genotoxic carcinogens
in transgenic mice harboring a human prototype c-Ha-ras gene than in control non-transgenic mice.
To evaluate the prevalence of genotoxic carcinogens
(39), we predicted the proportion of chemicals that would induce cancers in rodents and mutagenicity in Salmonella (i.
This analysis confirms that genotoxic carcinogens
are generally characterized by an ability to cause tumors in multiple species and at multiple sites (13, 14) whereas nongenotoxic agents tend to exhibit tissue- and species-specific carcinogenicity (Table 11) (4,13,15).