Among the different types of exposures to a genotoxic
compound, occupational exposure is very important, as the individual is continuously and directly in contact with the compound.
IPCS guidelines for the monitoring of genotoxic
effects of carcinogens in humans.
cordifolia as alternative source of natural compounds to cure genotoxic
- related problems.
With respect to the results listed in Table 2, the orange and grape juices of the five food companies, at both exposure times considered, induced significant formation of mitotic spindle changes, represented in this study by colchicine metaphase and anaphase and telophase bridges, proving to be genotoxic
, and chromosome breaks, characterized by the formation of micronuclei.
effect of metals on freshwater mussels is very important to assess the aquatic health and could be suggested as biomarker.
Accordingly, ZnO nanorods genotoxic
evaluation administered orally in Swiss mice for a 7 day period with the lowest possible inevitable exposure doses was aimed.
This study also concluded that comet bioassay can be used for in-vivo experiments, using fish as a model for the screening of genotoxic
and mutagenic pollutants in aquatic environment.
Cells exposed to a genotoxic
environment may act in different manners.
The studies related to the impact of genotoxic
exposure in an organism, therefore, not only cover an attempt to elucidate the mechanism(s) involving direct changes to the genetic material, but also the genotoxic
effects and changes at the level of gene pool and population .
5] and evidence supporting that a genotoxic
mode of action is still insufficient .
1) Based on this strong evidence, it would be useful to know if and to what extent radiotherapy causes genotoxic
and cytotoxic effects resulting in DNA damage on oral mucosa.
In addition, occupational exposure to pesticides poses major threats including adverse reproduction, congenital anomalies and genotoxic
effects (Hussain et al.