Researchers say that with a better understanding of genomic imprinting
, a host of complex, inherited diseases may finally begin to make genetic sense.
Two novel genes in the center of the 11p15 imprinted domain escape genomic imprinting
NASDAQ:ILMN) today announced that researchers at Baylor College of Medicine's Medical Genetics Laboratories will use Illumina's Infinium[R] High-Density (HD) DNA Analysis products to study genomic imprinting
and its role in developmental diseases such as Prader-Willi syndrome (PWS), Angelman syndrome (AS), and other disorders caused by uniparental disomy.
Methylation of promoter CpG islands is associated with histone deacetylation and transcriptional silencing (1) and is essential for normal embryonic development, genomic imprinting
, and X-chromosome inactivation.
Exploratory Grants for Genomic Imprinting
and Environmental Disease Susceptibility
But the legacies of our parents linger on at the molecular level as well, in the form of genes that may act differently depending on which parent provided them--a phenomenon called genomic imprinting
, which is related to why mammals persist in requiring parents of both sexes.
Prader-Willi syndrome is the result of a phenomenon known as genomic imprinting
The epigenetic analysis of maternal plasma has obvious applications to disorders associated with genomic imprinting
, such as Prader-Willi syndrome (25).
VOLUME 1 I MOLECULAR GENETICS Genetics, Molecular Basis of DNA Replication and Transcription Translation of RNA to Protein Alternatively Spliced Genes Repair and Mutagenesis of DNA Genomic Imprinting
, Molecular Genetics of Heterochromatin and Euchromatin-Organization, Packaging II GENOMIC ORGANISATION AND EVOLUTION Gene Distribution in the Human Genome Anthology of Human Repetitive DNA Repetitive sequence and noncoding DNA evolution in Eukaryotes Horizontal Gene Transfer Molecular Systematics and Evolution Genetic Variation and Molecular Evolution III GENOMES OF MODEL ORGANISMS E.
Eight leading scientists will make presentations on meiotic versus mitotic chromatin structure and function, transcriptional repression prior to MET, genomic imprinting
, chromatin structure and gene expression, the relationship between DNA replication and transcription, the role of the nuclear envelope, and somatic versus embryonic cell cycle.
The role of genomic imprinting
in human developmental disorders: lessons from Prader-Willi syndrome.
and X-inactivation) in reproduction, and other topics in reproductive genetics.