genome-wide association study


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genome-wide association study

A research study that compares all of the DNA of people affected by an illness with the DNA of matched healthy individuals. Its aim is to identify specific genetic variations that make some people more likely than others to become sick. These variations (mutations) are often minor, consisting of as little as a change in a single nucleotide in a DNA strand.
References in periodicals archive ?
We applied the Genome-wide Association Study (GWAS) to complement the best linear unbiased prediction (BLUP).
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
To investigate the genetic architecture of Graves' disease, Rujin Hospital researchers conducted a genome-wide association study in 1,536 individuals with Graves' disease (cases) and 1,516 controls.
2012) performed the genome-wide association study of swine farrowing traits and identified 124 statistically significant SNPs.
First ever genome-wide association study on common, incurable skin condition pinpoints two genetic variants associated with rosacea
The international team performed a genome-wide association study meta-analysis on a total of over 100,000 subjects of European and Asian descent - 29,880 rheumatoid arthritis patients and 73,758 controls - by analysing around 10 million genetic variants called single nucleotide polymorphism (SNPs).
The team carried out a genome-wide association study to identify any common gene variants that might correlate with which hand people prefer using.
Two common genetic variants on chromosomes 6p21 and 16q24 were found to be associated with Barrett's esophagus in the first genome-wide association study of susceptibility to the disorder, according to a letter to the editor.
performed a large genome-wide association study to further evaluate sequence variants affecting population variation in PSA concentration (5).
In the largest genome-wide association study (GWAS) reported to date involving Alzheimer's disease, scientists have identified two new possible genetic risk factors for late-onset Alzheimer's, the most common form of the disease.
For example, a genome-wide association study of 1 million SNPs will flag about 50,000 SNPs as significant.