association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.
The creation of this genome-wide
premade adenoviruses collection that is readily available will benefit researchers who work with difficult-to-transfect primary cells and stem cells, as well as any other researchers who use full-length cDNA clones.
ChIP-on-chip analysis of target genes of RORA, as well as additional methods of validation, confirmed that RORA transcriptionally regulates the genes A2BP1, CYP19A1, HSD17B10, ITPR1, NLGN1, and NTRK2, such that when RORA levels are cut in half, all six genes also go down in their expression.
To overcome this limitation and test the hypotheses that general flowering is triggered by the proposed factors, we conducted an "ecological transcriptome" study of a mass flowering species, Shorea beccariana, comparing meteorological data with genome-wide
expression patterns obtained using next-generation sequencing.
ANALYSIS OF TRANSLATIONAL REGULATION OF PATHOGEN-MEDIATED CELLULAR STRESS SIGNALING IN ARABIDOPSIS THALIANA "XIAOYU LIU", J LUCAS BOATWRIGHT, KRISTIN S ROCKETT, KAROLINA M MUKHTAR DEPARTMENT OF BIOLOGY, UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL 35205.
In the largest genome-wide
association study, or GWAS, ever conducted in Alzheimer's research, investigators studied DNA samples from more than 56,000 study participants and analyzed shared data sets to detect gene variations that may have subtle effects on the risk for developing Alzheimer's.
The investigators performed a genome-wide
analysis of large, rare chromosomal deletions and duplications known as copy number variants (CNVs) in 366 children with ADHD and 1,047 controls.
The spirit that drove the genome sequencing projects has lived on in the era of genome-wide
association (GWA) studies, where the intense competition between groups has driven forward genetic research at an impressive pace in the last 36 months, producing dramatic genetic associations that often explain large proportions of disease pathogenesis.
As has been shown by recent publications and in-house screening work we have done," he continued, "CRISPR mediated knockout provides a powerful approach for these type of screens and we developed this genome-wide
library to enable more researchers to utilize this new technology.
The objective of this proposal is to elucidate the genetic and epigenetic signature of transcription termination genome-wide
using a combination of computational, genetic and biochemical approaches.
association study (GWAS) is a standard approach for studying the genetics of natural variation, typically focusing on association between single-nucleotide polymorphisms (SNPs) and traits.
Therefore, it is desirable to detect genetic variation that is effective for the expression of traits using high density genome-wide
significant single nucleotide polymorphism (SNP) rather than to study minor genetic variation by candidate gene approach (Liu and Dekkers, 1998).