The team's most recent study suggested that genistein
can protect BRCA1, a gene that plays a pivotal role in thwarting tumor development in breast tissue.
Although soy formulas are considered to be safe, infants fed soy formula have blood concentrations of genistein
that overlap with those showing biologic effects in rodents (Cao et al.
In one recent study Kamboh and Zhu (2014) did not display any influence of genistein
on villus height and crypt depth of intestinal segments.
Effect of dietary genistein
on antioxidant enzyme activities in SENCAR mice.
sup] The other case–control study nested in the European Prospective Investigation into Cancer and Nutrition also reported that higher plasma concentrations of genistein
were associated with lower risk of PCa; however, the relation between plasma concentrations of daidzein, equol, enterolactone or enterodiol, and PCa risk was not observed.
Resveratrol has been reported to extend lifespan in animal studies and it's been suggested genistein
could play a role in the prevention of some cancers, including breast cancer.
Of many phytoestrogens, genistein
(GEN), 4',5,7-trihydroxyisoflavone, was firstly extracted from dyer's broom by Perkin.
The growth of both estrogen-dependent and estrogen-independent breast cancer cells has been inhibited by genistein
Previous report has showed that treatment of NB4 and HL-60 xenograft mice with soy isoflavone genistein
combined with chemotherapy agent significantly increased survival time in comparison to untreated control group.
Research conducted by the team, described in 1996 in Clinical & Experimental Metastasis and in Molecular Pharmacology in 1997, demonstrated that genistein
dose-dependently inhibited human prostate cancer cell detachment, which is due to the isoflavone's ability to increase cell adhesion.
A US study published last year, demonstrated the safety of high doses of Genistein
Alygone in patients with Sanfilippo disease.
01% 17 beta-estradiol gel (n = 15); group 2: 4% genistein
isoflavone gel (n = 15).