genetic variability


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Related to genetic variability: Genetic diversity, heritability

genetic variability

1. The range of minor alterations present in a genome, such as the number of diverse alleles of a specific gene that are found as a result of small mutations in the DNA of a species.
2. The expression of those diverse genes in living organisms and their impact on health or disease.
See also: variability

genetic variability

a range of phenotypes for a particular CHARACTER produced by alternative alleles of one or more genes, the range containing discrete groups (see QUALITATIVE INHERITANCE or a continuous spectrum of types (see POLYGENIC INHERITANCE). Genetic variability arises initially by MUTATION and is maintained by sexual reproduction involving CROSSING OVER in MEIOSIS. Such variation is the raw material for NATURAL SELECTION to act upon, ensuring that the best-adapted variants are most likely to reproduce.
References in periodicals archive ?
Currently, existing OACs, such as warfarin, are suboptimal due to their propensity to interact negatively with commonly prescribed drugs, and due to widespread genetic variability in clearance.
Deer as wildlife are often exposed to extensive loss of genetic variability as a result of increasing isolation and subdivision of wild populations by alteration of the landscape and constant slaughtering by humans for venison, hides and antlers, and for sports.
To that end, this study will seek to expand and improve an understanding of how genetic variability affects response to prescribed medications to help improve medication choices and efficacy, and minimize side effects - potentially resulting in improved patient care.
The number of partners was predicted by genetic variability, said Simmons.
Genetic variability in human immunodeficiency viruses.
But in the western swath, the genetic variability in the chipmunks is telling, and it's lower at southern sites than at northern ones.
The National Cancer Institute (NCI) is interested in projects that can potentially lead to meaningful improvements in clinical and survival endpoints, and in studies of genetic variability in human populations that may influence risk of preneoplastic conditions or primary and secondary malignancies after exposure to medications, including cancer therapies.
Genizon conducts genome-wide association studies involving more than 40,000 members of the Quebec Founder Population, whose extensive genetic sharing and low genetic variability are ideally suited for the discovery of genes affecting people worldwide in the many common diseases with strong genetic components.
29 /PRNewswire-FirstCall/ -- A new genetic substudy of PLATO (A Study of PLATelet Inhibition and Patient Outcomes) showed that the effects on a combined primary endpoint of cardiovascular death, myocardial infarction, or stroke seen in Acute Coronary Syndromes (ACS) patients who received the investigational oral antiplatelet treatment, ticagrelor (BRILINTA(TM)), were maintained, whether or not they had the genetic variability that has been previously shown to affect a patient's response to clopidogrel.
In addition, genetically important individuals for the maintenance of genetic variability of the sub-breed were also identified through the core set method.
We tested for HCoV-NL63 in children with acute respiratory tract infection hospitalized in Caen from November 2002 to April 2003, described symptoms associated with this infection, and examined local strains for the genetic variability.