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genetic polymorphism

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genetic polymorphism,
the recurrence within a population of two or more discontinuous genetic variants of a specific trait in such proportions that they cannot be maintained simply by mutation. Examples include the sickle cell trait, the Rh factor, and the blood groups. Compare balanced polymorphism.

polymorphism [pol″e-mor´fizm]
the ability to exist in several different forms.
balanced polymorphism an equilibrium mixture of homozygotes and heterozygotes maintained by natural selection against both homozygotes.
genetic polymorphism the occurrence together in the same population of two or more genetically determined phenotypes in such proportions that the rarest of them cannot be maintained merely by recurrent mutation.
single nucleotide polymorphism (SNP) a genetic polymorphism between two genomes that is based on deletion, insertion, or exchange of a single nucleotide.


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Some subjects discussed are molecular chaperones in normal and pathologic states, genetic polymorphism of immunoproteasome and its functional value, and genetic polymorphism of alpha-1-inhibitor of proteinases and its clinical value.
Another paper published recently (Dig Liver Dis 2008 Oct 15, Epub ahead of print) indicates that there is a common genetic polymorphism that confers susceptibility to autoimmune thyroid disease in celiac children.
quot;What is new here is that for the first time they have identified the consequences of this genetic polymorphism (type) in how the brain functions," said Dr.
 
 
 
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