genetic load


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Related to genetic load: balanced polymorphism

ge·net·ic load

the aggregate of more or less harmful genes that are carried, mostly hidden, in the genome that may be transmitted to descendants and cause morbidity and disease; in classic genetic dynamics, genetic load may be seen as undischarged genetic debts that result from previous mutations, each of which is supposed to exact an average number of lethal equivalents dependent only on the pattern of inheritance, regardless of how mild or severe the phenotype may be.

genetic load

n.
1. The relative difference between the theoretically most fit genotype within a population and the average genotype.
2. The aggregate of deleterious genes that are carried, mostly hidden, in the genomes of a population and may be transmitted to descendants.

genetic load

the average number of accumulated detrimental genes per individual within a population, including those caused by mutation and selection within a recent generation and those inherited from ancestors. Genetic load is expressed in lethal equivalents.

ge·net·ic load

(jĕ-net'ik lōd)
The aggregate of more or less harmful genes that are carried, mostly hidden, in the genome and may be transmitted to descendants and cause disease.

genetic load

The totality of abnormalities caused in each generation by defective genetic material carried in the human gene pool.

genetic load

a measurement of the amount of deleterious genes in a population, calculated as the average number of lethal equivalents per individual.
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References in periodicals archive ?
Tetraploid alfalfa is known to carry a high genetic load of deleterious recessive alleles (Busbice, 1968, 1996; Bingham, 1983; Woodfield and Bingham, 1995; Kimbeng, 1996).
Epistasis influences the rate at which the genetic load can be purged with inbreeding.
Most of the data on reduction of the genetic load are from studies of self-compatible plants.
Holsinger (1988) and Uyenoyama and Waller (1991a,b,c) predict that variation in genetic load should become associated with variation in mating systems.
The goal of our study was to document variation among dams in their genetic load and test whether these differences were accounted for by differences in mating-system characters.
The results of this study suggest that under natural open-pollination, survival of progenies from different parents is not directly related to differences in additive genetic effects or genetic load among parents.
For every fitness component except P[2nd litter], the variation among founder lineages within replicates in response to inbreeding was highly significant, indicating that the genetic load expressed for various traits measured within the laboratory environment was not evenly partitioned among the genomes of different founders.
truncatus is an allotetraploid species and that in such species the genetic load is expected to be lower than in diploid species (Lande and Schemske 1985), though a thorough theoretical analysis has still to be performed.
The aim of this study was to quantify inbreeding depression and genetic load in the satyrid butterfly Bicyclus anyhana (Butler) to assess the impact of genetic bottlenecks in a Lepidopteran and to provide comparative data for previous studies, mainly on Drosophila and Musca.
Deleterious mutations, evolution, genetic load, inbreeding depression, mating system, selfing rate.
This would tend to minimize the decline in estimated genetic load if one compared outbred with more inbred populations.
A number of theoretical models have indicated that the genetic load due to recessive lethal mutations is rapidly purged from a population following even a small amount of inbreeding, whereas that component of the load due to mildly deleterious mutations or to polygenic mutations is difficult to purge (Lande and Schemske 1985; Charlesworth and Charlesworth 1987; Charlesworth et al.