genetic heterogeneity

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Related to genetic heterogeneity: Incomplete penetrance

ge·net·ic het·er·o·ge·ne·i·ty

the character of a phenotype produced by mutation at more than one gene or by more than one genetic mechanism. See: genocopy.


1. pertaining to reproduction or to birth or origin.
2. inherited.

genetic abnormality
inherited defect, which may or may not be congenital.
genetic analysis
analysis of breeding and pedigree records to establish degrees of relationship between single animals and groups of animals. Segregation analysis with full-sibling families is an obvious technique.
genetic code
the manner in which the arrangement of nucleotides in the polynucleotide chain of a chromosome governs the transmission of genetic information to proteins, i.e. determines the sequence of amino acids in the polypeptide chain making up each protein synthesized by the cell. Genetic information is coded in DNA by means of four bases (two purines: adenine and guanine; and two pyrimidines: thymine and cystosine). Each adjacent sequence of three bases (a codon) determines which of the 20 amino acids will be inserted into the nascent polypeptide.
genetic complementation
genetic control of inherited disease
consists of preventing carrier animals from contributing their genes to succeeding generations of the population of which they are members.
genetic correlation
a change in an unselected character resulting from selection of another character during a breeding program.
genetic defects
defects of function or structure passed on from parents to offspring. Inherited defects.
genetic determination
see broad-sense heritability.
genetic disease resistance
inherited resistance to diseases caused by non-hereditary risk factors.
genetic dominance
see dominance (2).
genetic drift
see antigenic drift.
genetic engineering
the manipulation of genes by recombinant DNA technologies to produce chromosomal combinations that are unlikely to occur by natural means, for example the introduction of genes for insulin into a yeast cell which then produces insulin which can be purified and used as a therapeutic substance. See also recombinant DNA technology.
genetic etiology
disease caused by inheritance of specific disease without the intervention of other risk factors; established by strongly positive relationship in terms of genes held in common between the affected patient and other affected individuals.
genetic evaluation
assessment, for predictive purposes, of productive improvement or conformational characteristics, of the gain to be derived by the use of the animal in question in a breeding program.
genetic expressivity
genetic heterogeneity
demonstrated by the way in which more than one disease with identical clinical signs can be inherited.
genetic immunization
use of a cloned genetically engineered gene with an encoded antigen to immunize the host against that antigen. See also DNA vaccine.
genetic map
the linear arrangement of genes along a chromosome. Called also linkage map.
genetic merit
inherited productivity or performance qualities.
mobile genetic elements
see transposable genetic elements (below).
genetic penetrance
genetic production potential
inherited productivity but still influenced by environmental risk factors.
genetic resistance
genetically determined resistance to specified infectious agents.
genetic selection
selection of animals as breeding stock on the basis of known inherited characteristics.
transposable genetic elements
pieces of DNA varying in length from a few hundred to tens of thousands of base pairs found in both prokaryotic and eukaryotic cells that move from place to place in the chromosomes of a single cell; some are viruses. Called also mobile genetic elements or transposons.
genetic variance
that portion of the phenotypic variance of a trait in a population which can be attributed to genetic difference amongst individuals.
References in periodicals archive ?
However, oceanographic features, such as gyres, or population isolation due to coastal geomorphology, could limit population mixing and lead to genetic heterogeneity.
Central to this framework is the acknowledgment that there is clinically relevant genetic heterogeneity within and between the OMB-defined racial/ ethnic groups.
Subcortical cysts and genetic heterogeneity of megalencephalic leukoencephalopathy.
Genetically complex diseases also typically exhibit genetic heterogeneity, which may relate to differences in clinical features (i.
Sanchez JM, Kaminker CE New evidence for genetic heterogeneity of the Freeman-Sheldon syndrome.
During histological progression into a morphologically identifiable lesion, the stochastic process of molecular events in different cells confers genetic heterogeneity.
Researchers only recently have begun to examine the clinical and genetic heterogeneity of autism and have found some significant differences in presentation.
Genetic heterogeneity among human papillomaviruses (HPV) associated with epidermodysplasia verruciformis: Evidence for multiple allelic forms of HPV5 and HPV8 E6 genes.
Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: a prospective evaluation of 52 families.
An Evaluation of Genetic Heterogeneity in 145 Breast-Ovarian Cancer Families," American Journal of Human Genetics 56 (1995): 254-64.
21,24-27] The pathogenicity of EBV may be enhanced by this genetic heterogeneity.