genetic disease

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genetic disease

A generic term for any–inherited condition caused by a defective gene–eg, an 'inborn error of metabolism'

Genetic disease

A genetic disease is a disease that is passed from one generation to the next, but does not necessarily appear in each generation. An example of genetic disease is Down's syndrome.
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genetic disease,

n a disease that is caused by a defect or anomaly in the genetic inheritance of the patient.

Patient discussion about genetic disease

Q. what makes Arthritis a genetic disease?

A. First of all, the term arthritis is a bit inaccurate: Arthritis denotes an inflammation of joints. There are many kinds of arthritis that may result from different causes, and therefore, are different diseases: septic arthritis (inflammation due to infection of joint) has much less genetic background than ankylosing spondylitis (an arthritis of the lower back joints that occurs almost exclusively in people with certain genetic background).

The arthritis with the genetic background are usually the autoimmune ones: Due to genetic determinants, the immune system of some people is programmed to recognize the various parts of the joints (and other organs as well) as foreign (i.e. like bacteria) and thus launches an attack on them. In normal immune system, that doesn't happen.

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Q. Is bipolar disease a hereditary problem? My only son is in his teens that is the age to enjoy life, but he cannot enjoy his life with his friends because we found that he is suffering from a bipolar condition. I feel so sad for him and though my care-free days have gone, I often think about how much fun I had at his age. I too suffered from a bipolar disorder and my mom too. Is bipolar disease a hereditary problem? I want him to help to enjoy his life.

A. I agree with you. No one should suffer because of hereditary problems. This is the same situation here as genes are passed from generation to generation. This information is inconclusive because many who may have had bipolar disorders did not have it checked out. Who is to say, how many people 50 years ago had it but dismissed it as being moody, or ill tempered. Doctors were not aware about this problem years ago. Some time back, someone who showed signs of a mental disorder was straight away shoved into a mental hospital and left to suffer. Besides they are often treated with electric shock therapy eventually getting out of control. Testing is still in progress to find out if genetics play a role but these theories may take several more years before they can have a better understanding.

Q. Is FMS heredetery? My mother was diagnosed with FMS and I would like to know what are the chances I’ll have it too.

A. Hereditary is not the right term. It’s not a genetic disease but The cause of fibromyalgia remains elusive. However, recent studies show that genetic factors can predispose individuals to a genetic susceptibility to fibromyalgia.

More discussions about genetic disease
References in periodicals archive ?
Steven Ory, Past President of the American Society for Reproductive Medicine: "After 30 years in reproductive medicine, I am more optimistic about this development in genetic disease prevention than I've ever been before.
At Genzyme we continue the mission to develop and deliver transformative therapies to all patients affected by rare genetic diseases.
The sequencing of genetic diseases will lead to a change in our medical practices.
4 million with deficiency allele combinations (phenotypes PiSS, PiSZ, and PiZZ) for the two most prevalent deficiency alleles PiS and PiZ; therefore, the new data suggest that AAT deficiency may be one of the most common serious single-locus genetic diseases in the world.
Although the new stem cells may eventually be used to treat the patients from whom they were cloned, study coauthor Gerald Schatten of the University of Pittsburg School of Medicine says that a more immediate use will be for studying genetic diseases.
Such "repeats" usually repeat themselves fewer than 30 times, but research has identified 18 human genetic diseases associated with expansion of the number of these repeats, sometimes into the thousands.
We recently began a Phase III trial with Aldurazyme (TM), an enzyme replacement product for patients with MPS-I, another of the MPS family of genetic diseases.
A father of four said his family was denied life insurance after he told the salesman he and two of his children were afflicted with Marfan's syndrome, a rare genetic disease which sometimes leads to a rupture of the aorta.
STAT-Seq can identify mutations across the genome associated with approximately 5,300 known genetic diseases, and in some cases even identify previously unknown genetic diseases.
Rich data from these assays is probed using advanced statistical and machine learning approaches, and the effects of thousands of known drugs and shelved drug candidates can be investigated efficiently to identify those holding the most promise for the treatment of any one rare genetic disease.
We have shown how genetic background -- that is, the unique set of DNA letters present in any person's genome -- influences the severity of any genetic disease," says Fraser, a professor in the University of Toronto's Donnelly Centre.
The fifth National Genetic Disease Conference, being held under the patronage of Shaikh Nahyan Bin Mubarak Al Nahyan, Minister of Culture, Youth and Community Development and President of UAE Genetic Disease Association, will host 800 participants from around the world at the World Trade Centre in Dubai on Sunday.