genetic association


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ge·net·ic as·so·ci·a·tion

the occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.

genetic association

a condition in which specific genotypes are associated with other factors, such as specific diseases.

ge·net·ic as·so·ci·a·tion

(jĕ-net'ik ă-sō'sē-ā'shŭn)
The occurrence together in a population, more often than can be readily explained by chance, of two or more traits of which at least one is known to be genetic.

genetic association

Evidence that a particular gene is responsible, or partly responsible, for a disease.
See also: association
References in periodicals archive ?
On this regard, Gustavsson et al [4] determined the effect of breed and genotype using composite genotypes of [kappa]-casein and [beta]-lactoglobulin genotypes to determine their genetic association with production traits.
Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies.
SNPs (single nucleotide polymorphisms) are used in genetic association studies to find out relationship between polymorphic alleles in the candidate gene and the disease status.
Genetic associations for drug-related adverse outcomes.
In contrast to the approaches used in the studies described above, genome-wide association studies (GWASs) investigate the genetic association with a disease using many SNPs that cover the entire genome instead of just a few genes.
Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association studies of complex diseases.
Conclusion: On the basis of results as summarized above, it is concluded that number of grains panicle-1, days to maturity, number of tillers plant-1 and 1000-grain weight have high broad sense heritability, strong genetic association and direct effect on paddy yield in studied rice genotypes.
In the present study, the nonsynonymous SNP rs1052133 located in the exonic region of the gene OGG1 was analyzed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis for association with the risk of squamous cell carcinomas of the head and neck (SCCHN) in a subpopulation cluster-matched (Indo-Europeans linguistic subgroup + Caucasoid morphological subtype) case-control based genetic association study.
For negative results, assessment of power to detect modest effects is crucial, and along with that, careful assessment of the likelihood of a false-positive finding in an apparent significant genetic association should also be made.
The true power of genetic association studies to identify risk factors for common diseases may in fact not lie in better identification of those at increased risk.
On the other hand, there may be more than one gene in the region or the genetic association may be due to some other genetic feature, such as a micro-RNA or a regulatory element that is acting at a distance.
org) was presented which provides a systematic summary of over 800 MS genetic association studies, and should help substantially in the interpretation of a complex field.