On this regard, Gustavsson et al  determined the effect of breed and genotype using composite genotypes of [kappa]-casein and [beta]-lactoglobulin genotypes to determine their genetic association
with production traits.
Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association
SNPs (single nucleotide polymorphisms) are used in genetic association
studies to find out relationship between polymorphic alleles in the candidate gene and the disease status.
for drug-related adverse outcomes.
In contrast to the approaches used in the studies described above, genome-wide association studies (GWASs) investigate the genetic association
with a disease using many SNPs that cover the entire genome instead of just a few genes.
Implications of small effect sizes of individual genetic variants on the design and interpretation of genetic association
studies of complex diseases.
Conclusion: On the basis of results as summarized above, it is concluded that number of grains panicle-1, days to maturity, number of tillers plant-1 and 1000-grain weight have high broad sense heritability, strong genetic association
and direct effect on paddy yield in studied rice genotypes.
In the present study, the nonsynonymous SNP rs1052133 located in the exonic region of the gene OGG1 was analyzed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing analysis for association with the risk of squamous cell carcinomas of the head and neck (SCCHN) in a subpopulation cluster-matched (Indo-Europeans linguistic subgroup + Caucasoid morphological subtype) case-control based genetic association
For negative results, assessment of power to detect modest effects is crucial, and along with that, careful assessment of the likelihood of a false-positive finding in an apparent significant genetic association
should also be made.
The true power of genetic association
studies to identify risk factors for common diseases may in fact not lie in better identification of those at increased risk.
On the other hand, there may be more than one gene in the region or the genetic association
may be due to some other genetic feature, such as a micro-RNA or a regulatory element that is acting at a distance.
org) was presented which provides a systematic summary of over 800 MS genetic association
studies, and should help substantially in the interpretation of a complex field.