generalized tonic-clonic seizure


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Related to generalized tonic-clonic seizure: grand mal seizure, grand mal epilepsy, grand mal

seizure

 [se´zhur]
1. the sudden attack or recurrence of a disease.
2. a convulsion or attack of epilepsy.
absence seizure the seizure seen in petit mal epilepsy, marked by a momentary break in the stream of thought and activity, accompanied by a symmetrical spike and wave at 3 cycles per second on the electroencephalogram. Called also petit malseizure. See epilepsy.
atonic seizure an absence seizure characterized by sudden loss of muscle tone.
complex partial seizure see partial seizure.
febrile seizure febrile convulsion.
focal seizure partial seizure.
focal motor seizure a simple partial seizure consisting of clonus or spasm of a muscle or muscle group, occurring either singly or in a continuous repetitive series.
generalized tonic-clonic seizure (grand mal seizure) the seizure seen in grand mal epilepsy, marked by loss of consciousness and generalized tonic convulsions followed by clonic convulsions. See epilepsy.
jackknife s's infantile spasms.
myoclonic seizure one characterized by a brief episode of myoclonus.
partial seizure any seizure due to a lesion in a specific, known area of the cerebral cortex; symptoms vary with different lesion locations. A simple partial seizure is the most localized type, with a discharge that is predominantly one-sided or presents localized features without loss of consciousness. A complex partial seizure is associated with disease of the temporal lobe and characterized by varying degrees of impairment of consciousness. See epilepsy.
petit mal seizure absence seizure.
reflex seizure (sensory seizure) an epileptic seizure in response to a sensory stimulus, which may be tactile, visual, auditory, or musical.
simple partial seizure see partial seizure.
tonic-clonic seizure see generalized tonic-clonic seizure.

gen·er·al·ized ton·ic-clo·nic sei·zure

a generalized seizure characterized by the sudden onset of tonic contraction of the muscles often associated with a cry or moan, and frequently resulting in a fall to the ground. The tonic phase of the seizure gradually give way to clonic convulsive movements occurring bilaterally and synchronously before slowing and eventually stopping, followed by a variable period of unconsciousness and gradual recovery.

generalized tonic-clonic seizure

Generalized seizure, grand mal seizure, tonic-clonic seizure Neurology A seizure of the entire body, characterized by muscle rigidity, violent rhythmic contractions, and loss of consciousness, with abnormal electric activity in neurons; GCTS may occur in anyone at any age, as a single episode or as a repeated, chronic condition–epilepsy, and are caused by abnormal electrical activity at multiple locations in the brain, or over most of the brain, which may be accompanied by changes in mental status–alertness, awareness and/or focal neurologic Sx Etiology Idiopathic, congenital defects and perinatal, metabolic defects, DM complications, electrolyte imbalances, kidney failure, uremia, nutritional deficiencies, PKU, alcohol or drugs, brain injury, tumors and space occupying lesions–eg, hematomas

gen·er·al·ized ton·ic-clo·nic sei·zure

, generalized tonic-clonic epilepsy (jen'ĕr-ă-līzd ton'ik-klon'ik sē'zhŭr, ep'i-lep'sē)
A generalized seizure characterized by the sudden onset of tonic contraction of the muscles often associated with a cry or moan, and frequently resulting in a fall to the ground. The tonic phase of the seizure gradually gives way to clonic convulsive movements occurring bilaterally and synchronously before slowing and eventually stopping, followed by a variable period of unconsciousness and gradual recovery.
Synonym(s): grand mal.

gen·er·al·ized ton·ic-clo·nic sei·zure

, generalized tonic-clonic epilepsy (jen'ĕr-ăl-īzd ton'ik-klon'ik sē'zhŭr, ep'i-lep'sē)
Seizure characterized by sudden onset of tonic contraction of muscles often associated with a cry or moan, and frequently resulting in a fall.
References in periodicals archive ?
This post-hoc analysis evaluated efficacy and tolerability of perampanel across all four Phase III studies in patients with secondarily generalized or primary generalized tonic-clonic seizures.
In patients on monotherapy, the sudden death risk for patients with one or two generalized tonic-clonic seizures was six times higher than that of controls; for those with three or more seizures, it was 12 times higher.
Mattson RH, Cramer JA, Collins JF: A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults.
All had either partial-onset or generalized tonic-clonic seizures and had been diagnosed with epilepsy within 3 months of entering the study The initial dosage of topiramate, 25 mg/day, was titrated up to 50 mg/day in 234 patients and to 400 mg/day in 236 patients.
levetiracetam for oral use as a prescription adjunctive therapy in the treatment of partial onset seizures, myoclonic seizures and primary generalized tonic-clonic seizures in adults and children with epilepsy.
Food and Drug Administration (FDA) has accepted for review the company's supplemental New Drug Application (sNDA) for its in-house developed antiepileptic drug Fycompa (generic name: perampanel) for the treatment of primary generalized tonic-clonic seizures (PGTC), a severe form of seizures, in patients 12 years or older.
Topiramate is approved only as add-on therapy to treat partial-onset seizures, primary generalized tonic-clonic seizures, or Lennox-Gastaut syndrome in adults and in children aged 2-16 years.
Potential to promote glaucoma zonisamide Approved by FDA for refractory (Zonegran) partial seizures; experience in other countries suggests it may also be useful for other types of seizures including generalized tonic-clonic seizures and myoclonic epilepsy.
Myoclonic: seizures characterized by jerking of a body extremity or generalized tonic-clonic seizures within an hour or two of waking from sleep.
Seeking Indication Expansion as Adjunctive Treatment of Primary Generalized Tonic-Clonic Seizures
A comparison of valproate with carbamazepine for the treatment of partial seizures and secondarily generalized tonic-clonic seizures in adults.
zonisamide Approved by FDA for refractory partial seizures; (Zonegran) experience in other countries suggests it may also be useful for other types of seizures including generalized tonic-clonic seizures and myocolonic epilepsy.

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