lipodystrophy

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Related to generalized lipodystrophy: congenital generalized lipodystrophy

lipodystrophy

 [lip″o-dis´tro-fe]
1. any disturbance of fat metabolism.
2. a group of conditions due to defective metabolism of fat, resulting in absence of subcutaneous fat; they may be congenital or acquired and partial or total. (See Atlas 2, Part F.)
congenital generalized lipodystrophy an autosomal recessive condition marked by the virtual absence of subcutaneous adipose tissue, large body size, splenomegaly, hirsutism, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.
intestinal lipodystrophy former name for Whipple's disease.
partial lipodystrophy a condition seen mainly in females in the first decade of life, characterized by symmetrical loss of subcutaneous fat, usually beginning on the face and gradually extending to the chest, neck, back, and upper limbs; this gives the lower part of the body an apparent, and possibly real, adiposity of the buttocks and lower limbs. Some affected patients develop insulin-resistant diabetes mellitus, triglyceridemia, and renal disease.
progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, facial emaciation, and abnormal accumulation of fat about the thighs and buttocks.
total lipodystrophy an autosomal recessive disorder occurring mainly in females, characterized by a generalized loss of subcutaneous fat and extracutaneous adipose tissue, present at birth or appearing later in life, and associated with hepatomegaly with abdominal protuberance, hypoglycemia and insulin-resistant nonketotic diabetes, hyperlipemia, marked elevation of the basal metabolic rate, accelerated somatic growth, advanced bone age, acanthosis nigricans and hirsutism.

lip·o·dys·tro·phy

(lip'ō-dis'trō-fē),
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes, seen in consequence of some protease inhibitor use in AIDS patients.
Synonym(s): cellulite (2) , lipodystrophia
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

/lipo·dys·tro·phy/ (-dis´tro-fe) any disturbance of fat metabolism.
congenital generalized lipodystrophy , congenital progressive lipodystrophy total l.
generalized lipodystrophy  total l.
partial lipodystrophy , progressive lipodystrophy progressive and symmetrical loss of subcutaneous fat from the parts above the pelvis, beginning with facial emaciation and progressing downward, giving an apparent and possibly real accumulation of fat about the thighs and buttocks.
total lipodystrophy  a recessive condition marked by the virtual absence of subcutaneous adipose tissue, macrosomia, visceromegaly, hypertrichosis, acanthosis nigricans, and reduced glucose tolerance in the presence of high insulin levels.

lipodystrophy

[lip′ōdis′trəfē]
Etymology: Gk, lipos + dys, bad, trophe, nourishment
any abnormality in the metabolism or deposition of fats. Kinds of lipodystrophy are congenital total lipodystrophy, familial partial lipodystrophy, insulin lipodystrophy, membranous lipodystrophy, and progressive lipodystrophy.
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Lipodystrophy

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
Defective metabolism of fat.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

A condition of disordered fat metabolism. There may be abnormal breakdown of fats with loss of weight, excessive levels of fats in the blood, raised blood sugar levels, enlargement of the liver and abnormal thyroid gland function. In some cases there is breakdown of fat from the upper part of the body and abnormal deposition around the buttocks and thighs. The condition can be caused by prolonged multiple antiretoviral therapy.

lip·o·dys·tro·phy

(lip'ō-dis'trŏ-fē)
1. Defective metabolism of fat.
2. Abnormal depositions or wastings of adipose tissue, or combinations of these changes.
[lipo- + G. dys-, bad, difficult, + trophē, nourishment]

lipodystrophy

(lip´ōdis´trəfē),
n an abnormality in the metabolism or deposition of fats.

lipodystrophy

any disturbance of fat metabolism.

porcine cerebrospinal lipodystrophy
References in periodicals archive ?
Patients with both types of generalized lipodystrophy often develop severe insulin resistance at a young age and may have diabetes mellitus that is difficult to control or very high levels of triglycerides in the blood (hypertriglyceridemia) that can lead to inflammation of the pancreas.
Myalept is the first approved therapy indicated for treating the complications associated with congenital or acquired generalized lipodystrophy and provides a needed treatment option for patients with this orphan disease, said Mary Parks, M.
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.

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