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generalized cortical hyperostosis

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generalized cortical hyperostosis

hyperostosis [hi″per-os-to´sis]
excessive growth of bony tissue. adj., adj hyperostot´ic.
frontal internal hyperostosis (hyperostosis fronta´lis inter´na) a new formation of bone tissue protruding in patches on the internal surface of the cranial bones in the frontal region, most commonly affecting women near menopause.
generalized cortical hyperostosis a hereditary disorder beginning during puberty, marked by osteosclerosis of the skull, mandible, clavicles, ribs, and diaphyses of long bones, associated with elevated blood alkaline phosphatase.
infantile cortical hyperostosis a syndrome seen in infants under six months of age, marked by fever, arthralgias, and swelling and cortical thickening of facial, trunk, and long bones. Called also Caffey's disease.

generalized cortical hyperostosis
van Buchem's disease, hyperostosis corticalis generalisata, sclerosteosis An AR osteoporosis complex of early onset with bony overgrowth of 1. BM, resulting in chronic cytopenias and 2. Cranial foramina, causing stenosis and facial nerve paresthesia, loss of vision, deafness Lab ↑ Alk phos


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