generalized Shwartzman phenomenon

gen·er·al·ized Shwartz·man phe·nom·e·non

(shwarts'măn),
when both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread hemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunologic basis.

gen·er·al·ized Shwartz·man phe·nom·e·non

(jen'ĕr-ă-līzd shvahrts'mahn fĕ-nom'ĕ-non)
When both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation. This reaction has no immunologic basis.

Shwartzman,

Gregory, Russian bacteriologist in U.S., 1896-1965.
generalized Shwartzman phenomenon - death occurs in an animal that has been injected with a primary injection of endotoxin-containing filtrate and secondary injection given intravenously 24 hours apart. Synonym(s): Sanarelli phenomenon; Sanarelli-Shwartzman phenomenon
Sanarelli-Shwartzman phenomenon - Synonym(s): generalized Shwartzman phenomenon
Shwartzman phenomenon - a rabbit injected intradermally with a small quantity of endotoxin followed by a second intravenous injection 24 hours later will develop a hemorrhagic and necrotic lesion at the site of the first injection. Synonym(s): Shwartzman reaction
Shwartzman reaction - Synonym(s): Shwartzman phenomenon
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