gene silencing


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gene silencing

The inhibition of transcription of a gene. DNA METHYLATION is an important cause of gene silencing and when this affects tumour-suppressor genes may be a cause of cancer.

gene silencing

A therapeutic technique to prevent the expression of genes that are acting harmfully. Double-stranded RNA molecules introduced into cells with viral vectors are processed by an enzyme known as dicer. This frees short interfering RNA segments (siRNAs) which are then unzipped into two RNA strands. These then produce a complex which binds to the complementary RNA coding for a protein thus preventing the synthesis of the protein. The potential for gene silencing seems considerable and may have a role in the management of cancer by blocking angiogenesis and of wet age-related macular degeneration and diabetic retinopathy.
References in periodicals archive ?
Molecular biologists, botanists, crop scientists, and other researchers review the current status of the theory of gene silencing and its application in plants.
Although Xist s regulation has been investigated intensively, less is known about the actual mechanisms underlying the process of chromosome-wide gene silencing that it induces.
Controversial gene silencing, also known as RNA interference (RNAi), was recently introduced with FDA approval for two new crops: apples that resist browning and potatoes that produce less acrylamide.
M2 PHARMA-August 9, 2013-Regen BioPharma Inc licenses cancer gene silencing technology, expanding its cancer vaccine patent portfolio(C)2013 M2 COMMUNICATIONS
M2 EQUITYBITES-August 9, 2013-Regen BioPharma Inc licenses cancer gene silencing technology, expanding its cancer vaccine patent portfolio(C)2013 M2 COMMUNICATIONS http://www.
The researchers investigated using nanoparticles to deliver double-stranded ribonucleic acid, dsRNA -- a molecule capable of specifically triggering gene silencing -- into mosquito larvae through their food.
One of the key means by which cells achieve this control is by "RNA interference," a form of gene silencing where small pieces of RNA, called micro RNAs, obstruct the production of specific proteins by interacting with their genetic code.
Scientists will use gene silencing to discover plant genes that play a role in orchestrating defense responses to P.
Research leader Samuel Gunderson, an associate professor in the Department of Molecular Biology and Biochemistry at Rutgers, claims that his team have developed highly efficient gene silencing agents that function via a novel mechanism of action.
Johnston, IA) has patented methods of controlling gene silencing using site-specific recombination.
Epigenetics refers to the study of gene silencing and non-Mendelian inheritance of traits.
Gene Silencing, or RNA interference (RNAi) uses target-specific sequences of short interfering RNA molecules (siRNA molecules) to knock-down, or "silence" targeted genes to infer their function.