gene dosage effect

gene dos·age ef·fect

in codominant alleles, the more or less linear relationship between the phenotypic value and the number of genes of one type substituted by another type.
References in periodicals archive ?
We found a gene dosage effect, the more unfavourable variations a woman has, the greater her ovarian cancer risk and the shorter her survival time," said senior author Xifeng Wu, M.
Although mutations within the PMP22 gene have been identified in some cases of CMT1A and HNPP, a gene dosage effect has been proposed as the principal underlying pathomechanism for development of CMT1A and HNPP (9-11).
It appears, however, that the comprehensive DS phenotype cannot be accounted for on the basis of gene dosage effects alone.
Transcript level alterations reflect gene dosage effects across multiple tissues in a mouse model of Down syndrome.
In addition to combining resistance genes, interchange stocks allow evaluation of putative allelic relationships and gene dosage effects.