We found a gene dosage effect
, the more unfavourable variations a woman has, the greater her ovarian cancer risk and the shorter her survival time," said senior author Xifeng Wu, M.
Proteolipid protein gene dosage effect
in Pelizaeus-Merzbacher disease.
Although mutations within the PMP22 gene have been identified in some cases of CMT1A and HNPP, a gene dosage effect
has been proposed as the principal underlying pathomechanism for development of CMT1A and HNPP (9-11).
It appears, however, that the comprehensive DS phenotype cannot be accounted for on the basis of gene dosage effects
Transcript level alterations reflect gene dosage effects
across multiple tissues in a mouse model of Down syndrome.
In addition to combining resistance genes, interchange stocks allow evaluation of putative allelic relationships and gene dosage effects