gemcitabine


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gemcitabine

 [jem-sit´ah-bēn]
an antineoplastic agent used in chemotherapy for pancreatic adenocarcinoma and non–small cell lung carcinoma; administered by intravenous infusion as the hydrochloride salt.

gemcitabine

/gem·cit·a·bine/ (jem-sit´ah-bēn) an antineoplastic agent used as the hydrochloride salt in the treatment of pancreatic adenocarcinoma and non.

gemcitabine

a miscellaneous antineoplastic.
indications It is used to treat adenocarcinoma of the pancreas (nonresectable Stages II and III or metastatic Stage IV) and non-small-cell lung cancer (Stages IIIA or B and IV). It is also used in combination with cisplatin to treat inoperable, advanced, or metastatic non-small-cell lung cancer.
contraindications Known hypersensitivity and pregnancy prohibit its use.
adverse effects Life-threatening effects are leukopenia, anemia, neutropenia, thrombocytopenia, and hemorrhage. Other adverse effects include diarrhea, nausea, vomiting, anorexia, constipation, stomatitis, irritation at the site of administration, rash, alopecia, dyspnea, fever, and infection.

gemcitabine

Gemzar Oncology An IV antimetabolic antineoplastic used with cisplatin for inoperable non-small cell lung CA, and as a single agent for inoperable pancreas CA Side effects ↓ WBCs and platelets; ↑ liver enzymes; 10% discontinued medication due to flu-like Sx, N&V, rash. See Cisplatin. Cf 5-FU.

gemcitabine

A CYTOTOXIC anticancer drug. A brand name is Gemzar.
References in periodicals archive ?
Using a combination of gemcitabine plus cisplatin as their chemotherapy drugs combined with hyperthermia therapy, the treatment reached their target for improvement, and based on these data a randomized first-line phase III clinical trial has been initiated.
Portrazza, in combination with gemcitabine and cisplatin, is the first biologic approved for first-line treatment of people with metastatic squamous non-small cell lung cancer
The discovery, which allows for a combination of decitabine and gemcitabine to be delivered in pill form, marks a major step forward in patient feasibility for the drugs, which previously had been available solely via injection or intravenous therapy (IV).
The use of IV-administered vitamin C in combination with cytotoxic chemotherapy is further encouraged by a recent report showing that vitamin C potentiated the antitumor activity of gemcitabine against 7 human and 1 murine pancreatic cancer cell lines.
ABRAXANE plus gemcitabine demonstrated highly statistically significant and clinically meaningful results across primary and key secondary endpoints and patient subgroups
The research by Cancer Research UK's Cambridge Research Institute showed in mice combining a chemotherapy drug called gemcitabine with an experimental drug called MRK003 sets off a chain of events that ultimately kills cancer cells.
Gemcitabine is the preferred drug for the adjuvant treatment due to the more favourable toxicity profile compared to bolus 5-FU.
The new multicenter, randomized, phase II and III trial compared gemcitabine with FOLFIRINOX (oxaliplatin, irinotecan, leucovorin, and fluorouracil) in 342 patients with metastatic pancreatic cancer.
In patients with unresectable (inoperable) pancreatic cancer, the combination of gemcitabine and a novel cationic liposomal formulation of paclitaxel called EndoTAG-1 substantially prolongs survival compared to gemcitabine therapy alone, according to a study presented last week.
study that evaluated pemetrexed plus cisplatin versus gemcitabine HCl for
ORLANDO -- Hopes that the addition of bevacizumab to gemcitabine would improve survival in patients with advanced pancreatic cancer have been dashed by the disappointing results of CALGB 80303, a phase III randomized trial presented at a symposium on gastrointestinal cancers sponsored by the American Society of Clinical Oncology.