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gemcitabine

   Also found in: Wikipedia 0.01 sec.
gemcitabine /gem·cit·a·bine/ (jem-sit´ah-bēn) an antineoplastic agent used as the hydrochloride salt in the treatment of pancreatic adenocarcinoma and non.
gemcitabine,
a miscellaneous antineoplastic.
indications It is used to treat adenocarcinoma of the pancreas (nonresectable Stages II and III or metastatic Stage IV) and non-small-cell lung cancer (Stages IIIA or B and IV). It is also used in combination with cisplatin to treat inoperable, advanced, or metastatic non-small-cell lung cancer.
contraindications Known hypersensitity and pregnancy prohibit its use.
adverse effects Life-threatening effects are leukopenia, anemia, neutropenia, thrombocytopenia, and hemorrhage. Other adverse effects include diarrhea, nausea, vomiting, anorexia, constipation, stomatitis, irritation at the site of administration, rash, alopecia, dyspnea, fever, and infection.

gemcitabine [jem-sit´ah-bēn]
an antineoplastic agent used in chemotherapy for pancreatic adenocarcinoma and non–small cell lung carcinoma; administered by intravenous infusion as the hydrochloride salt.

gemcitabine
Gemzar Oncology An IV antimetabolic antineoplastic used with cisplatin for inoperable non-small cell lung CA, and as a single agent for inoperable pancreas CA Side effects ↓ WBCs and platelets; ↑ liver enzymes; 10% discontinued medication due to flu-like Sx, N&V, rash. See Cisplatin. Cf 5-FU.


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They tested the activity of the TAK-1 inhibitor on its own and in combination with the anti-cancer drugs gemcitabine, oxaliplatin and SN-38 (a metabolite of the anti-cancer drug irinotecan) in cell lines, and the activity of the TAK-1 inhibitor combined with gemcitabine against pancreatic cancer in mice.
No difference between adjuvant 5-FU/FA and gemcitabine in pancreatic cancer The European Study Group for Pancreatic Cancer-3 trial [ESPAC-3 (v2)] was an international multicentre study set up to compare adjuvant chemotherapy with 5-fluorouracil/folinic acid (5-FU/FA) and gemcitabine (GEM) to see if either produced significantly longer survival rates [3].
It is usually combined with gemcitabine if used during chemotherapy to achieve the targeted therapy.
 
 
 
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