gemcitabine


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gemcitabine

 [jem-sit´ah-bēn]
an antineoplastic agent used in chemotherapy for pancreatic adenocarcinoma and non–small cell lung carcinoma; administered by intravenous infusion as the hydrochloride salt.

gemcitabine

/gem·cit·a·bine/ (jem-sit´ah-bēn) an antineoplastic agent used as the hydrochloride salt in the treatment of pancreatic adenocarcinoma and non.

gemcitabine

a miscellaneous antineoplastic.
indications It is used to treat adenocarcinoma of the pancreas (nonresectable Stages II and III or metastatic Stage IV) and non-small-cell lung cancer (Stages IIIA or B and IV). It is also used in combination with cisplatin to treat inoperable, advanced, or metastatic non-small-cell lung cancer.
contraindications Known hypersensitivity and pregnancy prohibit its use.
adverse effects Life-threatening effects are leukopenia, anemia, neutropenia, thrombocytopenia, and hemorrhage. Other adverse effects include diarrhea, nausea, vomiting, anorexia, constipation, stomatitis, irritation at the site of administration, rash, alopecia, dyspnea, fever, and infection.

gemcitabine

Gemzar Oncology An IV antimetabolic antineoplastic used with cisplatin for inoperable non-small cell lung CA, and as a single agent for inoperable pancreas CA Side effects ↓ WBCs and platelets; ↑ liver enzymes; 10% discontinued medication due to flu-like Sx, N&V, rash. See Cisplatin. Cf 5-FU.

gemcitabine

A CYTOTOXIC anticancer drug. A brand name is Gemzar.
References in periodicals archive ?
Keywords: Glioblastoma multiforme (GBM), Radiosensitizer, Gemcitabine.
An analysis of patients with newly diagnosed, locally advanced pancreatic cancer treated with up to 6 cycles of Abraxane + gemcitabine as an investigational induction therapy (n=106) found that patients had a median time to treatment failure of 8.
However, results from the Phase III IMPACT trial revealed that Abraxane in combination with gemcitabine, when compared to gemcitabine monotherapy, increased median overall survival by 1.
For arm B, the doses were for gemcitabine 2000 [+ or -] 160 mg and for cisplatin 100 [+ or -] 20 mg.
Patients received two dose levels of DKN-01 in combination with gemcitabine and cisplatin.
Results: A significant effect in tumour growth over time was observed for gemcitabine and the combination therapy compared to the control group.
Four cycles of gemcitabine and docetaxel; combination chemotherapy were administered to the patients.
This need has most recently led the bladder cancer community to investigate the role of intravesical over intravenous gemcitabine as an agent for bladder preservation.
Those who had been treated with Abraxane plus gemcitabine lived an average of 1.
University of Minnesota researchers first announced decitabine and gemcitabine could potentially combine to treat HIV in research published in August 2010.
The findings of the CTCA study, coupled with the emerging evidence from the available literature, suggest that the combination of IV-administered vitamin C with gemcitabine to treat pancreatic cancer is a therapeutic approach that warrants further evaluation.
The research by Cancer Research UK's Cambridge Research Institute showed in mice combining a chemotherapy drug called gemcitabine with an experimental drug called MRK003 sets off a chain of events that ultimately kills cancer cells.