In CBC's previous 200 patient plasma gelsolin epidemiology study, this group proved themselves to be a highly competent team of clinical research professionals.
Gelsolin is a highly evolutionary conserved, naturally occurring protein found inside cells as well as in plasma.
In particular, CBC is currently focused on a theranostic approach to treat critical care patients with low plasma gelsolin (pGSN) levels at high risk of life-threatening complications.
2+], gelsolin severs and caps polymeric actin filaments (F-actin) (21): after binding of domain G1 and partly domain G2 to the actin filament (F-actin), gelsolin rapidly severs F-actin and then remains bound to the barbed end of one of the newly formed filaments, forming a stable cap, thus inhibiting addition of further monomers.
The concentration of gelsolin seems to be rate limiting in the actin removal system and depends on the rates of formation, dissociation, and clearance of the actin-gelsolin complex.
There are 3 major Gc-globulin responses in tissue injury (25): One response is in the actin-scavenging system, working in concert with gelsolin, as described above.
In particular, CBC is focused on a theranostic approach to treat critical care patients with low plasma gelsolin
levels at high risk of life-threatening complications.
Biogen's Gelsolin is the recombinant form of a natural actin-severing agent that is thought to work by reducing airway mucus viscosity in patients with respiratory diseases like cystic fibrosis and chronic bronchitis.
Based on our pre-clinical studies, we believe Gelsolin has potential as a treatment for respiratory diseases, which constitute large and underserved markets.
expression and retarded collagen lattice contraction with smooth muscle cells from Crohn's diseased intestine.
Gelsotin-derived amyloid (AGel; familial, prototype Finnish) is a rare disorder, reported worldwide in kindreds carrying a gelsolin gene mutation.
Partial proteolysis of the precursor protein is consistently seen in AA and AL; significant fragmentation also occurs in TTR, amyloid derived from gelsolin, cystatin C, AD, and apolipoprotein AI.