gelsolin


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Related to gelsolin: Profilin

gel·so·lin

(jel-sol'in), [MIM*137350]
An actin-binding protein; a Ca2+-triggered actin-filament-severing protein; hence, it has roles in locomotion, secretion, and endocytosis.

gelsolin

(jĕl′sŏl′ĭn)
n.
A calcium-regulated actin-binding protein that breaks cytoskeletal actin filaments into smaller pieces, thus transforming the actin network (or gel) into a colloidal solution and influencing cell morphology, motility, and apoptosis.
References in periodicals archive ?
Among insoluble lens proteins, vimentin, gelsolin, gamma enolase like protein, filensin like protein and ATP synthase subunit B were found from lenses of Uromastyx hardwickii.
There were no differences in mean CSF gelsolin level between 0 and 24 hours in all groups.
coli appears to be the host of choice for optimizing cloning performance and maximizing production efficiency of proteins like plasma gelsolin," said CBC's Chief Executive Officer, Mr.
We recently reported unique "millipede-like" structures in mammalian cell cytoskeletons revealed after removal of actin by treatment with gelsolin (Svitkina et al.
Critical Biologics Corporation (CBC) today announced the successful enrollment of the first four patients in its "first-in-man" clinical trial for Solinex[TM], an intravenous formulation of recombinant human plasma gelsolin (rhu-pGSN).
Homozygous familial amyloidosis, Finnish type: demonstration of glomerular gelsolin-derived amyloid and non-amyloid tubular gelsolin.
Thus, a complex actin-scavenging system has evolved in the vascular compartment, which involves 2 proteins: Gc-globulin and gelsolin (Fig.
The preclinical and prognostic clinical data generated by CBC's founding scientists is very impressive, and the therapeutic potential of recombinant human plasma gelsolin looks to be extremely promising from every perspective.
2]-microglobulin ATTR Transthyretin AFib Fibrinogen A a-chain AApoAI Apolipoprotein AI AApoAII Apolipoprotein AII ALys Lysozyme AGel Gelsolin ACys Cystatin C Amyloid Protein Syndrome AL/AH Multiple myeloma/plasma cell dyscrasia-associated, also known as primary AA Sporadic: secondary; familial: periodic fevers (b) (familial Mediterranean fever, other) ALect 2 Renal-nephrotic syndrome and/or liver-chronic hepatitisc A[[beta].
Protein (a) Biological function How expressed in this study Gelsolin Extracellular Decreased early actin scavenger (C) (b) system Transthyretin Transthyretin- Increased in retinol binding recovery stage complex prevents (F) glomerular loss of retinol Complement Involved in the Decreased early component C3 release of the (F) and in inflammatory fulminant stage mediators, (C) anaphylatoxins; acute-phase reactant [[alpha].
The funds will enable CBC to advance its lead recombinant human plasma gelsolin (rhu-pGSN) targeted for the prevention of life-threatening critical care complications associated with low plasma gelsolin levels.
37) Other coregulators of AR function include ARA70, p300, CBP, Tip60, ARA55, ARA54, gelsolin, Stat3, and RAC3.