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Pepsin B; a metalloproteinase that hydrolyzes gelatin and a number of types of collagen. See: pepsin.



MMP-2; MMP-9

Metalloproteinases that cleave gelatin, or nondenatured collagen. Two forms of gelatinase, A and B, have been identified. Gelatinase A (MMP-2) has a molecular weight of about 72,000, and gelatinase B (MMP-9) has a molecular weight of about 92,000. Both are involved in cancer angiogenesis and metastasis and are blocked by a variety of naturally occurring and synthetic inhibitors.
References in periodicals archive ?
Traits that may enhance the virulence include the usual suspects cytolysin, aggregation substance, adhesions, extracellular superoxide (ESO), extracellular surface protein (ESP), haemolysin and gelatinase (5).
Latent and active forms of gelatinase A were characterized from guanidine HC1 extracts of rat cervixes from non-pregnant rats, and pregnant rats at day 11, 17, term and 4 days post partum using gel zymography and/or western blot analyses (1, 2).
The phenotypic determination of possible virulence factors showed that the isolates (VP1-VP3 and VR1-VR3) all produced [beta]-hemolysis on rabbit blood agar, lecithinase, proteinase, gelatinase, and DNase.
This increased pressure phenomenon apparently leads to osteoclastic activation for resorption of bone, presumably from the elevated cytokines (prostaglandins, (13) interleukin 1[beta], and gelatinase (14)) released by the endothelial cells lining the cyst wall.
The results show that both the 62kD collagenase and the 92kD gelatinase have increased activity in obese kidneys.
Doxycycline is thought to inhibit gelatinase, which breaks down components of the skin's extracellular matrix.
The Chanel laboratories have developed an ultra-targeted formula called Precision Age Delay Eye, which combines extract, of horse chestnut with a marine polysaccharide (a powerful inhibitor of gelatinase A, an enzyme said to play a key role in the aging of the eye area), and a lipopeptide, also used in the Age Delay serum for the face.
mannitol motility test, indole production test, urease test, citrate utilization, methyl red test, voges-proskauer's test, catalase test, oxidase test, nitrate reduction test, aminoacid utilization test, test for production of amylase, caseinase, dnase, sugar utilization test, phenylalanine deaminase test, cellulase test, ONPG (P-galactosidase enzyme), gelatinase test, H2S production test, melonate test for characterization and identification of the isolated bacteria (7,8).
The isolation, characterization, and molecular cloning of a 75-kDa gelatinase B-like enzyme, a member of the matrix metalloproteinase (MMP) family.
SalA showed selectivity on gelatinase (MMP-2 and MMP-9) than on collagenase (MMP-8 and MMP-13) in vitro, and specificity on MMP-9 than MMP-2 in vivo.