gatifloxacin


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gatifloxacin

 [gat″ĭ-flok´sah-sin]
a broad-spectrum antibiotic effective against many gram-positive and gram-negative bacteria; administered orally and intravenously in the treatment of bacterial complication of chronic bronchitis, acute sinusitis, community-acquired pneumonia, gonorrhea, pyelonephritis, and urinary tract infections due to susceptible organisms.

gatifloxacin

/gat·i·flox·a·cin/ (gat″ĭ-flok´sah-sin) a fluoroquinoloneantibacterial effective against many gram-positive and gram-negative bacteria.

gatifloxacin

a broad-spectrum antiinfective.
indications It is used to treat acute bacterial exacerbation of chronic bronchitis, acute sinusitis, community-acquired pneumonia, gonorrhea, and infections caused by susceptible Escherichia coli, Staphylococcus aureus, Haemophilus influenzae, H. parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis, Neisseria gonorrhoeae, Proteus mirabilis, Chlamydia pneumoniae, Legionella pneumophila, and Mycoplasma pneumoniae.
contraindications Known hypersensitivity to quinolones prohibits its use.
adverse effects Pseudomembranous colitis is a life-threatening effect. Other adverse effects include dizziness, insomnia, paresthesia, tremor, vasodilation, increased aspartate aminotransferase and alanine aminotransferase, pruritus, urticaria, photosensitivity, flushing, fever, and chills. Common side effects include headache, nausea, diarrhea, rash, dyspnea, and pharyngitis.

gatifloxacin

a fluoroquinolone antibiotic with activity against anaerobic bacteria.
References in periodicals archive ?
Bacterial Conjunctivitis Drugs Market, by Drug Class Fluoroquinolones Ciprofloxacin Ofloxacin Levofloxacin Moxifloxacin Gatifloxacin Besifloxacin Aminoglycosides Tobramycin Gentamycin Macrolides Erythromycin Azithromycin Others U.
Unlike the Bangladesh study (4), the Karakalpakstan study used moxifloxacin instead of gatifloxacin and included scheduled electrocardiograms (ECGs) and graded assessments of side effects to monitor for safety, including cardiac toxicity.
Gatifloxacin (Tequin[R]) was withdrawn from the market in 2006 because of its association with dysglycemia, and these antibiotics may cause hypoglycemia by increasing the body's release of insulin.
This so called 'Bangladesh' regimen consists of high-dose isoniazid, high-dose gatifloxacin, kanamycin, prothionamide, ethambutol, pyrazinamide and clofazimine given for only 9 months and is now being compared with the standard 18 --24-month regimen in The Evaluation of a Standardised Treatment Regimen of Anti-Tuberculosis Drugs for Patients with Multidrug-Resistant Tuberculosis (STREAM), an International Union Against Tuberculosis and Lung Disease sponsored, non-inferiority clinical trial.
5-4 [micro]g/mL), gatifloxacin (GAT; 1-8 [micro]g/mL), ciprofloxacin (CIP; 0.
Activity of gatifloxacin tested against isolates from pediatric patients: report from the SENTRY Antimicrobial Surveillance Program (North America, 1998-2003).
In January 2008, he was referred to Orebro, Sweden, where he was treated parenterally with amoxacillin-clavulanic acid, metronidazole, amikacin, and gatifloxacin.
The following antibiotics (all supplied from Hi Media Laboratories, Mumbai, India) were tested: ceftriaxone (30ug), cefoperazone (75[micro]g), cefixime (30ug), ceftazidime (30[micro]g), cefepime (30[micro]g), cefpirome (30[micro]g), gentamicin (10[micro]g), amikacin (30[micro]g), ofloxacin (5[micro]g), gatifloxacin (5[micro]g) and aztreonam (30[micro]g).
For them the only effective second-line antimicrobials are moxifloxacin and gatifloxacin.
A large retrospective case-control study completed within the Veterans Administration (VA) documented that the increased CDAD rates observed were not associated with fluoroquinolone formulary change to gatifloxacin but with seasonal variation in CDAD rates (28).
These include ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), 1evofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and sparfioxacin (Zagam).
difficile susceptibility to clindamycin and moxifloxacin were used; MICs for levofloxacin and gatifloxacin were interpreted by using criteria for moxifloxacin (13).