gastroparesis


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Related to gastroparesis: gastroenteritis, vagus nerve

gastroparesis

 [gas″tro-pah-re´sis]
paralysis of the stomach; called also gastroparalysis and gastroplegia.

gas·tro·pa·re·sis

(gas'trō-pă-rē'sis, -par'ĕ-sis),
Weakness of gastric peristalsis, which results in delayed emptying of the bowels.
[gastro- + G. paresis, a letting go, paralysis]

gastroparesis

/gas·tro·pa·re·sis/ (gas″tro-pah-re´sis) paralysis of the stomach.

gastroparesis

(găs′trō-pə-rē′sĭs, -păr′ĭ-sĭs)
n. pl. gastropare·ses (-sēz′)
A disorder characterized by delayed movement of food from the stomach into the small intestine because of impaired stomach motility, resulting in nausea, vomiting, and a feeling of fullness.

gastroparesis

[-pərē′sis]
1 paralysis of the stomach.
2 failure of the stomach to empty caused by decreased gastric motility. The major causes are various kinds of abdominal inflammation, scleroderma, diabetic autonomic neuropathy, vagotomy, and use of anticholinergic medications.

gastroparesis

Partial paralysis of gastric smooth muscle, resulting in retention of food.

Aetiology
Autonomic neuropathy due to diabetes, gastric surgery, vagal nerve damage, viral infections, medications (e.g., anticholinergics and narcotics), gastro-oesophageal reflux disease (GERD/GORD), smooth muscle disease (amyloidosis, scleroderma), metabolic disease (e.g. hypothyroidism).

Clinical findings
Abdominal pain, nausea, vomiting, bloating, loss of appetite, gastric muscle spasms, variable glucose levels.

Diagnosis
Upper GI endoscopy, ultrasonography, radio contrast studies, gastric emptying scintigraphy, breath test, Smart Pill.

gas·tro·pa·re·sis

(gas'trō-păr-ē'sis)
A slight degree of gastroparalysis.
[gastro- + G. paresis, a letting go, paralysis]

Gastroparesis

Nerve damage of the stomach that delays or stops stomach emptying, resulting in nausea, vomiting, bloating, discomfort, and weight loss.
Mentioned in: Sildenafil Citrate

gas·tro·pa·re·sis

(gas'trō-păr-ē'sis)
Weakness of gastric peristalsis, resulting in delayed emptying of the bowels.
[gastro- + G. paresis, a letting go, paralysis]

Patient discussion about gastroparesis

Q. is anyone following a diet for gastroparesis? i developed a bezoar in the stomach, as a result of gastroparesis and it caused internal bleeding, was wondering of anyone else has or knows someone who has had a similar experience

A. brandon

well i had vegus nerve severed also many years ago (forty or so) never gave me trble till recently everything seems ok rite now, but i think it may br an ongoing thing

thanks

Q. I have just been diagnosed with gastroparesis. I'am looking for more info on treatment and experiences...

A. In most cases, treatment does not cure gastroparesis—it is usually a chronic condition. Treatment helps you manage the condition so you can be as healthy and comfortable as possible..there are medications that helps like Metoclopramide (Reglan) that stimulates stomach muscle contractions to help emptying. and dietary changes (having 6 small meals instead of big three..) and there even clinical trials with Botulinum Toxin that might be helpful, but still in research.

More discussions about gastroparesis
References in periodicals archive ?
The most common known cause of gastroparesis is long-standing diabetes.
The randomized, double-blind, placebo-controlled, adaptive, parallel-group study assessed relamorelin 10 mcg administered once daily, twice daily, or placebo-administered daily to patients with diabetic gastroparesis over a period of one month.
Diabetic gastroparesis and symptomatic documented GERD are growing health issues among adults in the United States.
We routinely hear from patients suffering from gastroparesis who are excited about the progress of our clinical programs and hopeful that a safe and effective therapy is forthcoming.
These IFFGD research grants will be used to explore new options for diagnosis and treatment of idiopathic gastroparesis.
Altos Therapeutics is committed to identifying and developing new medicines for gastrointestinal disorders in areas of high unmet medical need, including gastroparesis, functional dyspepsia, refractory gastroesophageal reflux disease (GERD), Parkinson's disease, and refractory nausea.
Tranzyme Pharma announced positive top-line results today from a Phase 2, double-blind, placebo-controlled study evaluating TZP-102 capsules in diabetic patients with gastroparesis, a serious disorder characterized by the inability of the stomach to empty food efficiently.
Rhythm has completed a successful Phase 2 trial of relamorelin for the treatment of diabetic gastroparesis and a second successful Phase 2 trial for chronic constipation.
At that time, baseline-adjusted levels were 24 ppm in the subjects who had gastroparesis, -8 ppm in the diabetic subjects who didn't have gastroparesis, and -2 ppm in the control subjects.
In Tranzyme's Phase 2 study of diabetic patients with advanced gastroparesis, ulimorelin, given intravenously once daily for four days, demonstrated clinically and statistically significant improvements in multiple gastroparesis-related symptoms, including vomiting and nausea.
In addition, GI functional disorders in Parkinson's disease patients can affect the upper GI tract, resulting in gastroparesis symptoms.
ATLANTA -- Botulinum toxin injected into the pylorus may be another way to treat refractory gastroparesis.