gastric mucin

gas·tric mu·cin

a white or yellowish powder that forms a viscous opalescent fluid with water, prepared from mucosa of hog's stomach by pepsin-hydrochloric acid digestion and precipitation of the supernatant fluid with 60% alcohol; used in peptic ulcer for its protective and lubricating action.

gastric mucin

Etymology: Gk, gaster, stomach; L, mucus
a viscous secretion of glycoproteins produced from the mucous membrane lining of swine stomachs and formerly used in the treatment of peptic ulcers.


A gene on chromosome 11p15.5 that encodes a gel-forming glycoprotein of gastric and respiratory tract epithelia, which protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles, which are subsequently removed by the mucocilary system.

Molecular pathology
MUC5A stains are positive in foveolar dysplasia.
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The gastric mucin content was determined as described by Winzler (2006) and was expressed in terms of mg % hexoses.
Administration of absolute ethanol in the ulcer control group produced the lowest content of gastric mucin content (0.
Based on the results of this study, the gastroprotective effect of ECF could be partly attributed to its ability to increase the gastric mucin content.
For example, several investigators report that a gastric mucin phenotype is a poor prognostic indicator, whereas other reports indicate the intestinal mucin phenotype to be associated with a worse outcome or to have no correlation with survival.
7,8,13) Mucin phenotypes were further subdivided into gastric (only gastric mucin positive) and gastric-predominant gastrointestinal phenotypes and intestinal (only intestinal mucin positive) and intestinal-predominant gastrointestinal phenotypes and null type based on the combination of predominant patterns of MUC5AC, MUC2, MUC6, and CD10 staining according to Tsukashita et al.
Alterations in gastric mucin with malignant transformation: novel pathway for mucin biosynthesis.
Nitric oxide as a modulator of gastric mucin synthesis: role of ERK and p38 mitogen activated protein kinase activation.
Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis.
Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients.
Inhibition of gastric mucin synthesis by Helicobacter pylori.
Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.