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gastric intrinsic factor

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gastric intrinsic factor (GIF),
n a substance secreted by the gastric mucosa that is essential for the intestinal absorption of vitamin B12; also known as
intrinsic factor.


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=>Pernicious anemia +Mechnisms: Chronic gastritis leading to lack of gastric intrinsic factor and failure of vitamin B12 absorption; vitamin B12 deficiency causes delayed DNA replication.
Conservative estimates indicate that 2-3% of this population has, or will develop, pernicious anemia, caused by failure of gastric intrinsic factor production, resulting in B12 mal-absorption.
 
 
 
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