gap junctions


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gap junctions

aligned protein membrane channels of two adjacent cells, allowing passage of low-molecular-weight solutes (ions, chemical messengers, amino acids and glucose) directly between cells

gap junctions

regions of high and special ionic permeability between closely apposed cells. They are places at which cells exchange molecules of large size and provide an avenue by which developing cells can influence each other. Called also nexus.

neuronal gap junctions
very tight contacts between some neurons permitting the almost instant transmission of impulses from one neuron to the other; structural elements extend across the gap conferring a continuity of cytoplasm between the cells.
References in periodicals archive ?
Further, it validates our strategy of targeting cellular communication via gap junctions in the discovery of innovative new drugs -- confirming our unique position in this rapidly advancing area of drug discovery," said Eva Steiness, CEO, Zealand Pharma.
When the researchers forced the cells to the verge of death using oxygen deprivation or chemical treatment and then mixed them with untreated healthy cells, the dying cells somehow induced the suicide of healthy cells connected to them by gap junctions.
In addition to chemical links across synapses, neurons can also form direct connections via electrical gap junctions.
Gap junctions form a network of bonded interconnecting GCs that surround the oocyte, and the loss of these junctions may facilitate the dissociation of the oocyte and disrupt normal folliculogenesis.
The basal cells are joined by gap junctions to intermediate cells and to fibrocytes of adjacent connective tissue, indicating exchanges between these three cell types.
Gap junctions are composed of connexin proteins that form intercellular channels allowing for direct communication among cells, and are involved in growth control.
Gap junctions are specialized cell-cell junctions that directly link the cytoplasm of neighboring cells.
related to gap junctions or ion channels), this division was used for the sake of simplification.
Moreover Connexin 43-ir gap junctions are abundant between myocytes in the circular muscle layer but not in the longitudinal muscle layer (7).
Tests showed that the product boosts keratinocyte differentiation by stimulating the expression of caspase-14 and improves intercellular connections by boosting the expression of connexin 43, a major component of gap junctions involved in cell-to-cell communication.
Within the mammalian heart, the distribution of connexin43 (Cx43)-containing gap junctions is essential to facilitating the coordinated spread of electrical activation throughout the cardiac muscle cells (cardiomyocytes) and allowing the heart to contract properly.