Further, it validates our strategy of targeting cellular communication via gap junctions
in the discovery of innovative new drugs -- confirming our unique position in this rapidly advancing area of drug discovery," said Eva Steiness, CEO, Zealand Pharma.
When the researchers forced the cells to the verge of death using oxygen deprivation or chemical treatment and then mixed them with untreated healthy cells, the dying cells somehow induced the suicide of healthy cells connected to them by gap junctions
In addition to chemical links across synapses, neurons can also form direct connections via electrical gap junctions
form a network of bonded interconnecting GCs that surround the oocyte, and the loss of these junctions may facilitate the dissociation of the oocyte and disrupt normal folliculogenesis.
The role of myocardial gap Junctions
in electrical conduction and arrhythmogenesis.
The basal cells are joined by gap junctions
to intermediate cells and to fibrocytes of adjacent connective tissue, indicating exchanges between these three cell types.
are composed of connexin proteins that form intercellular channels allowing for direct communication among cells, and are involved in growth control.
are specialized cell-cell junctions that directly link the cytoplasm of neighboring cells.
related to gap junctions
or ion channels), this division was used for the sake of simplification.
Moreover Connexin 43-ir gap junctions
are abundant between myocytes in the circular muscle layer but not in the longitudinal muscle layer (7).
Tests showed that the product boosts keratinocyte differentiation by stimulating the expression of caspase-14 and improves intercellular connections by boosting the expression of connexin 43, a major component of gap junctions
involved in cell-to-cell communication.
Within the mammalian heart, the distribution of connexin43 (Cx43)-containing gap junctions
is essential to facilitating the coordinated spread of electrical activation throughout the cardiac muscle cells (cardiomyocytes) and allowing the heart to contract properly.