2) It has been described as an inflammation resulting from spontaneous torsion, subsequent ischemia, and eventually gangrenous necrosis
of the appendage or by primary thrombosis of the draining vein and inflammation.
The infection may start along the fascial plane and cause symptoms including erythematous, painful, and edematous skin lesions which often rapidly deteriorate to hemorrhagic blisters, anesthesia, and gangrenous necrosis
over several days.
The surgical pathology of the left above-the-knee amputation showed multifocal ulcerations and gangrenous necrosis
with marked acute inflammation and granulation tissue.