gammopathy


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Related to gammopathy: polyclonal gammopathy

gammopathy

 [gam-mop´ah-the]
abnormal proliferation of the lymphoid cells producing immunoglobulins; the gammopathies include multiple myeloma, macroglobulinemia, and Hodgkin's disease. Called also gammaglobulinopathy.
monoclonal g's plasma cell dyscrasias.

gam·mop·a·thy

(gă-mop'ă-thē),
A primary disturbance in immunoglobulin synthesis.

gammopathy

/gam·mop·a·thy/ (gam-op´ah-the) abnormal proliferation of the lymphoid cells producing immunoglobulins; the gammopathies include multiple myeloma, macroglobulinemia, and Hodgkin's disease.

gammopathy

[gamop′əthē]
an abnormal condition characterized by the presence of markedly increased levels of gamma globulin in the blood. Two different types of hypergammaglobulinemia can be distinguished. Monoclonal gammopathy is commonly associated with an electrophoretic pattern showing one sharp, homogenous electrophoretic band in the gamma globulin region. This reflects the presence of excessive amounts of one type of immunoglobulin secreted by a single clone of B lymphocytes. Polyclonal gammopathy reflects the presence of a diffuse hypergammaglobulinemia in which all immunoglobulin classes are proportionally increased. See also Bence Jones protein, multiple myeloma.

gammopathy

An abnormal ↑ in immunoglobulin production; monoclonal gammopathies–MGs are usually malignant Examples Myeloma, Waldenström's disease, CLL, heavy-chain disease, but may also be benign, appearing in amyloidosis and MG of undetermined significance; polyclonal gammopathies are usually benign and appear in inflammatory conditions–eg, angioimmunoblastic lymphadenopathy, cirrhosis, leishmaniasis, rheumatoid arthritis, SLE, TB. Note: Polyclonal gammopathies may occur as epiphenomena in lymphomas, Hodgkin's disease, metastatic adenoCA. See Biclonal gammopathy, Monoclonal gammopathy of undetermined significance.

gam·mop·a·thy

(gă-mop'ă-thē)
A primary disturbance in immunoglobulin synthesis.

gammopathy

Any abnormality, in quality or quantity, of the IMMUNOGLOBULINS present in the blood. Benign monoclonal gammopathy is an abnormal production of a single clone of an immunoglobulin. Gammopathies are associated with MYELOMATOSIS.

gammopathy

abnormal proliferation of the B lymphocytes resulting in abnormal levels of immunoglobulin production; the gammopathies include multiple myeloma, macroglobulinemia and Hodgkin's disease. Called also gammaglobulinopathy.

monoclonal gammopathy
an increased production of one type of immunoglobulin by a single clone of cells. The abnormal protein produced is called paraprotein or M component and may be composed of whole immunoglobulin molecules or subunits, light-chains (Bence Jones proteins) or heavy-chains. Occurs in myelomas, lymphoproliferative neoplasms, and occasionally chronic inflammatory or immune-mediated diseases. Greatly elevated serum levels of protein may result in a hyperviscosity syndrome.
polyclonal gammopathy
a hypergammaglobulinemia resulting from an increased production of several different immunoglobulins and usually attributable to persistent, high level exposure to antigens; occur in a wide variety of infectious, inflammatory, and immune-mediated diseases. Examples in animals are feline infectious peritonitis, canine ehrlichiosis, Aleutian mink disease and equine infectious anemia.
References in periodicals archive ?
Carbamazepine induced transient monoclonal gammopathy and immunodeficiency.
Extramedullary plasmacytoma of the thyroid associated with a serum monoclonal gammopathy.
Patients with monoclonal gammopathy of undetermined significance (MGUS) are typified by a serum M-protein value of < 30g/L, fewer than 10% plasma cells in the bone marrow, none or a small amount of M protein in the urine, and absence of lytic bone lesions, anemia, hypercalcemia or renal insufficiency related to the plasma cell proliferative process (Kyle 2005).
Key words: high density lipoprotein (HDL), total protein, immunophoresis, protein electrophoresis, multiple myeloma, monoclonal gammopathy.
For more than 15 years he had been monitored by doctors for a condition called Monoclocal Gammopathy of Undetermined Significance (MGUS) in which he had abnormal protein in his blood.
19) The patient presented with severe anemia, monoclonal gammopathy, high erythrocyte sedimentation rate, and significant weight loss.
The doctors' findings also may have implications for the estimated 1 million people in the United States who have been diagnosed with an apparent precursor to multiple myeloma, called monoclonal gammopathy, of undetermined significance.
In humans, Potter says, plasma cell cancer appears infrequently The most common manifestation of a human plasma cell proliferation is monoclonal gammopathy of undetermined significance (MGUS), which produces benign tumors.
At this time she is considered to have a monoclonal B cell lymphocytosis with the immunophenotype of chronic lymphocytic leukemia/lymphoma and a plasma cell dyscrasia that may represent monoclonal gammopathy of uncertain significance.
Consequently, bone marrow biopsy was performed to further evaluate the monoclonal gammopathy.