gammopathy


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Related to gammopathy: polyclonal gammopathy

gammopathy

 [gam-mop´ah-the]
abnormal proliferation of the lymphoid cells producing immunoglobulins; the gammopathies include multiple myeloma, macroglobulinemia, and Hodgkin's disease. Called also gammaglobulinopathy.
monoclonal g's plasma cell dyscrasias.

gam·mop·a·thy

(gă-mop'ă-thē),
A primary disturbance in immunoglobulin synthesis.

gammopathy

/gam·mop·a·thy/ (gam-op´ah-the) abnormal proliferation of the lymphoid cells producing immunoglobulins; the gammopathies include multiple myeloma, macroglobulinemia, and Hodgkin's disease.

gammopathy

[gamop′əthē]
an abnormal condition characterized by the presence of markedly increased levels of gamma globulin in the blood. Two different types of hypergammaglobulinemia can be distinguished. Monoclonal gammopathy is commonly associated with an electrophoretic pattern showing one sharp, homogenous electrophoretic band in the gamma globulin region. This reflects the presence of excessive amounts of one type of immunoglobulin secreted by a single clone of B lymphocytes. Polyclonal gammopathy reflects the presence of a diffuse hypergammaglobulinemia in which all immunoglobulin classes are proportionally increased. See also Bence Jones protein, multiple myeloma.

gammopathy

An abnormal ↑ in immunoglobulin production; monoclonal gammopathies–MGs are usually malignant Examples Myeloma, Waldenström's disease, CLL, heavy-chain disease, but may also be benign, appearing in amyloidosis and MG of undetermined significance; polyclonal gammopathies are usually benign and appear in inflammatory conditions–eg, angioimmunoblastic lymphadenopathy, cirrhosis, leishmaniasis, rheumatoid arthritis, SLE, TB. Note: Polyclonal gammopathies may occur as epiphenomena in lymphomas, Hodgkin's disease, metastatic adenoCA. See Biclonal gammopathy, Monoclonal gammopathy of undetermined significance.

gam·mop·a·thy

(gă-mop'ă-thē)
A primary disturbance in immunoglobulin synthesis.

gammopathy

Any abnormality, in quality or quantity, of the IMMUNOGLOBULINS present in the blood. Benign monoclonal gammopathy is an abnormal production of a single clone of an immunoglobulin. Gammopathies are associated with MYELOMATOSIS.

gammopathy

abnormal proliferation of the B lymphocytes resulting in abnormal levels of immunoglobulin production; the gammopathies include multiple myeloma, macroglobulinemia and Hodgkin's disease. Called also gammaglobulinopathy.

monoclonal gammopathy
an increased production of one type of immunoglobulin by a single clone of cells. The abnormal protein produced is called paraprotein or M component and may be composed of whole immunoglobulin molecules or subunits, light-chains (Bence Jones proteins) or heavy-chains. Occurs in myelomas, lymphoproliferative neoplasms, and occasionally chronic inflammatory or immune-mediated diseases. Greatly elevated serum levels of protein may result in a hyperviscosity syndrome.
polyclonal gammopathy
a hypergammaglobulinemia resulting from an increased production of several different immunoglobulins and usually attributable to persistent, high level exposure to antigens; occur in a wide variety of infectious, inflammatory, and immune-mediated diseases. Examples in animals are feline infectious peritonitis, canine ehrlichiosis, Aleutian mink disease and equine infectious anemia.
References in periodicals archive ?
Monoclonal gammopathy of undetermined significance and risk of infections: a population-based study.
In contrast to the latter reports that showed most patients had monoclonal gammopathy of undetermined significance (MGUS), one of our patients was diagnosed with C3GP just after the diagnosis of symptomatic MM and a second patient evolved from smoldering to symptomatic myeloma a few years after the diagnosis of MPGN (retrospectively reviewed and confirmed as C3GP).
Serum protein electrophoresis or serum immunofixation electrophoresis are also recommended in patients over age 60, because monoclonal gammopathy is a common cause of peripheral neuropathy in this age group.
Buadi, "Advances in the diagnosis, classification, risk stratification, and management of monoclonal gammopathy of undetermined significance: implications for recategorizing disease entities in the presence of evolving scientific evidence," Mayo Clinic Proceedings, vol.
Serum free light chain is an independent risk factor for progression in monoclonal gammopathy of undetermined significance.
Monoclonal gammopathy and subsequent multiple myeloma in a patient on chronic diphenylhydantoin therapy.
IgG type multiple myeloma and concurrent IgA type monoclonal gammopathy of undetermined significance complicated by necrotizing skin ulcers due to type I cryoglobulinemia.
It tends to involve the head and neck rather than the extremities, and in most cases the sclerodermiform plaques and lichenoid papules are associated with a monoclonal gammopathy
Polyclonal gammopathy is a common finding in HIV, and Tathiah and colleagues present a retrospective study of serum electrophoresis patterns in patients in KZN.
cincinnatiensis were described in a 73-year-old woman with nephrotic syndrome and idiopathic immunoglobulin gammopathy (6).