gamma-interferon


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gamma-interferon

n.
A lymphokine produced by macrophages and T cells that is involved in regulation of the immune system and activation of phagocytes.
References in periodicals archive ?
This is potential important news, because it suggests that gamma-interferon might represent a therapeutic target," said Galli.
Normally, when an infectious agent enters the body, `T-cells' respond by producing gamma-interferon.
These responses can be triggered by using an adenovirus to ferry gamma-interferon into animals before they become sick.
If this works, a bird that's treated with the gamma-interferon might still get infected with coccidia, but it might not lose as much weight or get as bad a case of coccidiosis," she explains.
It's been shown in mammalian cells that when you add gamma-interferon to a weak antigen, you get a greater immune response than if you just vaccinate with the antigen alone.
Axtell (now a postdoctoral scholar in Steinman's lab), Steinman and their colleagues were able to induce two superficially similar forms of EAE in mice by directing the myelin-attacking T cells to predominantly secrete either gamma-interferon or IL-17, respectively.
The new study failed to verify that mechanism, but Gallin says his own, unpublished results show that phagocytes obtained from the blood of gamma-interferon patients show enhanced fungus-killing ability in the test tube.
At the same time, the prospect of lifelong gamma-interferon treatment for people with CGD raises safety concerns, especially for infants and children.
Inducing IL-27 and gamma-interferon shut down the inflammation process by influencing the release of another interleukin, IL-17, that is a newly discovered component in maintaining the inflammation and autoimmune process.

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