gamma-glutamylcysteine synthetase

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γ-glu·ta·myl·cys·teine syn·the·tase

an enzyme that catalyzes the first step in glutathione biosynthesis, reacting l-glutamate, l-cysteine, and ATP to form γ-glutamylcysteine, ADP, and orthophosphate; inhibited by thiols such as glutathione and cysteamine.
References in periodicals archive ?
Sulforaphane also induces expression of gamma-glutamylcysteine synthetase light subunit but not the heavy subunit, and this induction is associated with moderate increases in intracellular glutathione levels.
Knock down of gamma-glutamylcysteine synthetase in rat causes a cetaminophen-induced hepatotoxicity.
Resistance of Leishmania donovani to sodium stibogluconate is related to the expression of host and parasite gamma-glutamylcysteine synthetase.
Cancer cells produce an enzyme called gamma-glutamylcysteine synthetase (GCS), which metabolizes and inactivates cyclophosphamide.
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